| Literature DB >> 1588563 |
B Hulin1, D A Clark, S W Goldstein, R E McDermott, P J Dambek, W H Kappeler, C H Lamphere, D M Lewis, J P Rizzi.
Abstract
A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety. These compounds lower blood glucose levels in the genetically obese and insulin-resistant ob/ob mouse. Appending an oxazole-based group at the terminus of the chain provided highly potent compounds.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1588563 DOI： 10.1021/jm00088a022
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446