| Literature DB >> 15885624 |
C Guigoni1, I Aubert, Q Li, V V Gurevich, J L Benovic, S Ferry, U Mach, H Stark, L Leriche, K Håkansson, Bernard H Bioulac, Christian E Gross, Pierre Sokoloff, Gilberto Fisone, E V Gurevich, Bertrand Bloch, Erwan Bezard.
Abstract
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Taking advantage of a monkey brain bank constituted to study the pathophysiology of levodopa-induced dyskinesia, we here report the changes affecting D1, D2 and D3 dopamine receptors within the striatum of four experimental groups of non-human primates: normal, parkinsonian, parkinsonian treated with levodopa without or with dyskinesia. We also report the possible role of arrestin and G protein-coupled receptor kinases.Entities:
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Year: 2005 PMID： 15885624 DOI： 10.1016/j.parkreldis.2004.11.005
Source DB: PubMed Journal: Parkinsonism Relat Disord ISSN： 1353-8020 Impact factor: 4.891