Literature DB >> 15885386

Functional outcome of intrathecal baclofen administration for severe spasticity.

Efstathios J Boviatsis1, Andreas T Kouyialis, Stefanos Korfias, Damianos E Sakas.   

Abstract

PURPOSE: To estimate the functional benefit in patients with severe spasticity treated with intrathecal baclofen infusion through an implantable pump and to stress the need for functional assessment of these patients with a functional scale. PATIENTS AND METHODS: Between 1999 and 2003, 22 patients with a long history of severe and disabling pharmaceutically intractable spasticity, underwent implantation of a pump for continuous intrathecal baclofen infusion. The patients were subdivided into two categories according to the aetiology of spasticity: 15 had Multiple Sclerosis and seven had suffered a Spinal Cord Injury at different levels (from C4 to T11). Clinical status was assessed with the Ashworth and Penn spasm scales. Functional benefits were evaluated with the Barthel index score and pain relief with a self-reported visual analogue pain scale.
RESULTS: Postoperatively, all patients presented improvement in spasticity, reduction of spasm frequency, significant improvement in functional status, enhancement of life comfort and reduction of pain.
CONCLUSION: Reduction of spasticity and spasms achieved with intrathecally delivered baclofen, leads to functional improvement and pain relief.

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Year:  2005        PMID: 15885386     DOI: 10.1016/j.clineuro.2004.09.007

Source DB:  PubMed          Journal:  Clin Neurol Neurosurg        ISSN: 0303-8467            Impact factor:   1.876


  10 in total

1.  The therapeutic effects of ablative neurosurgical procedures on the spinal cord for intractable spinal spasticity.

Authors:  Bunpot Sitthinamsuwan; Pornchai Khumsawat; Luckchai Phonwijit; Sarun Nunta-Aree; Akkapong Nitising; Sirilak Suksompong
Journal:  Spinal Cord Ser Cases       Date:  2017-06-08

2.  Introduction of an N-glycan sequon into HEXA enhances human beta-hexosaminidase cellular uptake in a model of Sandhoff disease.

Authors:  Kazuhiko Matsuoka; Daisuke Tsuji; Sei-Ichi Aikawa; Fumiko Matsuzawa; Hitoshi Sakuraba; Kohji Itoh
Journal:  Mol Ther       Date:  2010-06-22       Impact factor: 11.454

3.  Intrathecal baclofen for spasticity management: a comparative analysis of spasticity of spinal vs cortical origin.

Authors:  April Saval; Anthony E Chiodo
Journal:  J Spinal Cord Med       Date:  2010       Impact factor: 1.985

4.  Intrathecal baclofen toxicity and deep coma in minutes.

Authors:  Yusuf Tunali; Hakan Hanimoglu; Taner Tanriverdi; Lale Hanci; Murat Hanci
Journal:  J Spinal Cord Med       Date:  2006       Impact factor: 1.985

5.  Modulation of Motor Cortex Activity After Intrathecal Baclofen Delivery in Chronic Thoracic Spinal Cord Injury.

Authors:  Ivana Štětkářová; Jiří Keller
Journal:  Front Neurol       Date:  2022-05-13       Impact factor: 4.086

6.  Baclofen pump pocket infection: a case report of successful salvage with muscle flap.

Authors:  Bishara S Atiyeh; Shady N Hayek; Ghassan S Skaf; Ali Al Araj; Roukoz B Chamoun
Journal:  Int Wound J       Date:  2006-03       Impact factor: 3.315

7.  Systemic naloxone infusion may trigger spasticity in patients with spinal cord injury: case series.

Authors:  Nancy L Brackett; Emad Ibrahim; Andrei Krassioukov; Charles M Lynne
Journal:  J Spinal Cord Med       Date:  2007       Impact factor: 1.985

8.  Management of pain in individuals with spinal cord injury: Guideline of the German-Speaking Medical Society for Spinal Cord Injury.

Authors:  Steffen Franz; Barbara Schulz; Haili Wang; Sabine Gottschalk; Florian Grüter; Jochen Friedrich; Jean-Jacques Glaesener; Fritjof Bock; Cordelia Schott; Rachel Müller; Kevin Schultes; Gunther Landmann; Hans Jürgen Gerner; Volker Dietz; Rolf-Detlef Treede; Norbert Weidner
Journal:  Ger Med Sci       Date:  2019-06-17

9.  Intrathecal baclofen therapy for spasticity: A compliance-based study to indicate effectiveness.

Authors:  Hussam Abou Al-Shaar; Ahmed Alkhani
Journal:  Surg Neurol Int       Date:  2016-08-02

Review 10.  Baclofen in the Therapeutic of Sequele of Traumatic Brain Injury: Spasticity.

Authors:  Adán Pérez-Arredondo; Eduardo Cázares-Ramírez; Paul Carrillo-Mora; Marina Martínez-Vargas; Noemí Cárdenas-Rodríguez; Elvia Coballase-Urrutia; Radamés Alemón-Medina; Aristides Sampieri; Luz Navarro; Liliana Carmona-Aparicio
Journal:  Clin Neuropharmacol       Date:  2016 Nov/Dec       Impact factor: 1.592

  10 in total

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