| Literature DB >> 15885304 |
Berit Schuhmann1, Alexander Dietrich, Serdar Sel, Christian Hahn, Martin Klingenspor, Marek Lommatzsch, Thomas Gudermann, Armin Braun, Harald Renz, Wolfgang Andreas Nockher.
Abstract
In the present study, we demonstrated a significant reduction of B lymphocytes in the blood, spleen and bone marrow of BDNF deficient mice. The observed developmental block in bone marrow B cell development was linked specifically to the Pre-BII stage. B lymphocytes express the BDNF receptors p75NTR and TrkB(gp95), while no BDNF expression was found. However, a strong BDNF expression was demonstrated in bone marrow stromal cells. An increase of intracellular free calcium [Ca2+]i in B lymphocytes after BDNF application confirms a direct responsiveness of B lymphocytes to BDNF. In conclusion, these results suggest a role of BDNF for normal B lymphocyte development through paracrine effects in the bone marrow.Entities:
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Year: 2005 PMID： 15885304 DOI： 10.1016/j.jneuroim.2005.01.023
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478