Literature DB >> 15883337

Effects of chronic lead exposure on 1H MRS of hippocampus and frontal lobes in children.

X-M Meng1, D-M Zhu, D-Y Ruan, J-Q She, L Luo.   

Abstract

The authors performed IQ testing and magnetic resonance spectroscopy on six lead-exposed and six control children. Levels of N-acetyl aspartate (neuronal density and mitochondrial metabolism), creatine + phosphocreatine (phosphate metabolism), and choline (membrane turnover) were decreased in four brain regions (left and right frontal, left and right hippocampus) in lead-exposed children vs controls. The reductions were right frontal > left frontal > hippocampus but were the same bilaterally in the hippocampus.

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Year:  2005        PMID： 15883337     DOI： 10.1212/01.WNL.0000160391.58004.D4

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  12 in total

1.  Evidence for altered hippocampal volume and brain metabolites in workers occupationally exposed to lead: a study by magnetic resonance imaging and (1)H magnetic resonance spectroscopy.

Authors:  Yue-Ming Jiang; Li-Ling Long; Xia-Yan Zhu; Hong Zheng; Xue Fu; Shi-Yan Ou; Dong-Lu Wei; Hai-Lin Zhou; Wei Zheng
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2.  Mitochondrial dysfunction in autism.

Authors:  Cecilia Giulivi; Yi-Fan Zhang; Alicja Omanska-Klusek; Catherine Ross-Inta; Sarah Wong; Irva Hertz-Picciotto; Flora Tassone; Isaac N Pessah
Journal:  JAMA       Date:  2010-12-01       Impact factor: 56.272

3.  Assessment of auditory brainstem function in lead-exposed children using stapedius muscle reflexes.

Authors:  S A Counter; Leo H Buchanan; Fernando Ortega; Jeannette van der Velde; Erik Borg
Journal:  J Neurol Sci       Date:  2011-05-05       Impact factor: 3.181

4.  A proton magnetic resonance spectroscopy study of the chronic lead effect on the Basal ganglion and frontal and occipital lobes in middle-age adults.

Authors:  Tsyh-Jyi Hsieh; Yi-Chun Chen; Chun-Wei Li; Gin-Chang Liu; Yu-Wen Chiu; Hung-Yi Chuang
Journal:  Environ Health Perspect       Date:  2009-02-09       Impact factor: 9.031

5.  Proton magnetic resonance spectroscopy in adults with childhood lead exposure.

Authors:  Kim M Cecil; Kim N Dietrich; Mekibib Altaye; John C Egelhoff; Diana M Lindquist; Christopher J Brubaker; Bruce P Lanphear
Journal:  Environ Health Perspect       Date:  2010-10-13       Impact factor: 9.031

6.  Response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercury.

Authors:  Olivier Boucher; Matthew J Burden; Gina Muckle; Dave Saint-Amour; Pierre Ayotte; Éric Dewailly; Charles A Nelson; Sandra W Jacobson; Joseph L Jacobson
Journal:  Environ Health Perspect       Date:  2011-12-05       Impact factor: 9.031

7.  Developmental lead exposure alters synaptogenesis through inhibiting canonical Wnt pathway in vivo and in vitro.

Authors:  Fan Hu; Li Xu; Zhi-Hua Liu; Meng-Meng Ge; Di-Yun Ruan; Hui-Li Wang
Journal:  PLoS One       Date:  2014-07-07       Impact factor: 3.240

8.  Toxic encephalopathy.

Authors:  Yangho Kim; Jae Woo Kim
Journal:  Saf Health Work       Date:  2012-11-30

9.  Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism.

Authors:  Eleonora Napoli; Sarah Wong; Cecilia Giulivi
Journal:  Mol Autism       Date:  2013-01-25       Impact factor: 7.509

10.  Proton magnetic resonance spectroscopic evidence of glial effects of cumulative lead exposure in the adult human hippocampus.

Authors:  Marc G Weisskopf; Howard Hu; David Sparrow; Robert E Lenkinski; Robert O Wright
Journal:  Environ Health Perspect       Date:  2007-01-03       Impact factor: 9.031
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