| Literature DB >> 15883005 |
Hiromitsu Saito1, Hideki Tsumura, Seiichi Otake, Akihiro Nishida, Takahisa Furukawa, Noboru Suzuki.
Abstract
We report a knock-in mouse expressing Cre recombinase from the translational initiation site (ATG) of the endogenous L7/Pcp-2 gene. The resulting Cre expression matches the pattern of L7/Pcp-2 expression that is restricted to cerebellar Purkinje cells and retinal cells. Moreover, the Cre mouse showed no significant behavioral abnormality. Thus, our novel Cre mouse can be used for generation of Purkinje cells and retinal cell-specific gene expression and/or knockout in mouse using the Cre/loxP system.Entities:
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Year: 2005 PMID： 15883005 DOI： 10.1016/j.bbrc.2005.04.043
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575