| Literature DB >> 15882803 |
Maurizio Facheris1, Kari J Strain, Timothy G Lesnick, Mariza de Andrade, James H Bower, J Eric Ahlskog, Julie M Cunningham, Sarah Lincoln, Mathew J Farrer, Walter A Rocca, Demetrius M Maraganore.
Abstract
To avoid the possible confounding effect of population stratification, we employed a discordant sibling study design and a liberalization of the sibling transmission disequilibrium test to confirm the association of the S18Y variant of the ubiquitin carboxi-terminal hydrolase L1 (UCHL1) gene with Parkinson's disease (PD). The study included 497 case-control pairs (427 case-unaffected sibling pairs and 70 case-unrelated control pairs). Analyses confirmed a significant inverse association of the UCHL1 S18Y polymorphism with PD overall (OR=0.18, 95% CI=0.05-0.64, p=0.002, recessive model) and in several strata.Entities:
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Year: 2005 PMID： 15882803 DOI： 10.1016/j.neulet.2005.02.008
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046