Literature DB >> 1588280

Membrane cofactor protein (CD46) protects cells from complement-mediated attack by an intrinsic mechanism.

T J Oglesby1, C J Allen, M K Liszewski, D J White, J P Atkinson.   

Abstract

The cleavage of C3 is a critical step for complement (C) activation in the classical and alternative pathways. This reaction is controlled by the regulators of C activation protein family. Membrane cofactor protein (MCP) is a cofactor for the factor I-mediated inactivation of C3b and C4b. As a widely distributed membrane protein, MCP may protect host cells from inadvertent C activation. Human MCP has recently been shown to protect transfected rodent cells from human C-mediated lysis. In this report the relationship of MCP expression to C3b deposition and cytoprotection was examined using NIH/3T3 cells transfected with human MCP and exposed to human serum as a source of C and naturally occurring anti-mouse antibody. MCP inhibited C3b deposition in a dose-dependent fashion and inhibited lysis of the mouse cells expressing it. MCP did not inhibit lysis on bystander cells. These results demonstrate the protective role of MCP, at the cellular level, by an intrinsic mechanism.

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Year:  1992        PMID： 1588280      PMCID： PMC2119264          DOI： 10.1084/jem.175.6.1547

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  19 in total

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Authors:  T J Oglesby; D White; I Tedja; K Liszewski; L Wright; J Van den Bogarde; J P Atkinson
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Journal:  J Immunol       Date:  1990-07-01       Impact factor: 5.422

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Journal:  J Exp Med       Date:  1988-07-01       Impact factor: 14.307
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