Literature DB >> 15882714

Development of exophytic tumor model for laparoscopic partial nephrectomy: technique and initial experience.

Josephine Hidalgo1, Jay Belani, Keegan Maxwell, David Lieber, Michael Talcott, Pam Baron, Caroline Ames, Ramakrishna Venkatesh, Jaime Landman.   

Abstract

OBJECTIVES: To develop and test a porcine model to help teach the techniques needed to perform laparoscopic partial nephrectomy (LPN), which is a technically challenging procedure with necessary reconstructive skills that are difficult to transfer.
METHODS: A tumor model was created by unilateral subcapsular percutaneous injection of liquid plastic (Smooth-Cast 320) in five pig kidneys. Five Washington University urologists performed LPN and assessed the efficacy of the tumor model. Subsequently, the tumor model was evaluated as a tool for teaching LPN during the Washington University Advanced Laparoscopic and Robotic Urologic Oncology Course. Twenty-eight participants performed unilateral porcine LPN with the tumor model. Questionnaires were used to assess the utility of this tumor model.
RESULTS: Unilateral tumors were successfully created in five pigs and remained intact during all LPN procedures. Visually, the tumors appeared as white exophytic masses. Ultrasonography revealed a well-circumscribed, hypoechoic lesion and a mean diameter of 2.02 cm. The mean operative time was 32.4 minutes. In subsequent testing, 24 (86%) of the 28 participants returned the questionnaire, and 96% responded that the tumor model had enhanced their LPN learning experience. Seven course participants (29%) reported problems with hemostasis, ultrasonography, or laparoscopic instrumentation. Two tumor model-related complications occurred. During the initial evaluation, one pig experienced a fatal pulmonary embolism of the plastic. During the course, a second animal experienced extravasation of the solution into the renal collecting system.
CONCLUSIONS: For surgical education purposes, the Smooth-Cast model is an effective surgical tool for LPN. Most of the surgeons in this evaluation believed the model enhanced their learning experience.

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Year:  2005        PMID: 15882714     DOI: 10.1016/j.urology.2004.12.002

Source DB:  PubMed          Journal:  Urology        ISSN: 0090-4295            Impact factor:   2.649


  5 in total

Review 1.  The new pig on the block: modelling cancer in pigs.

Authors:  Tatiana Flisikowska; Alexander Kind; Angelika Schnieke
Journal:  Transgenic Res       Date:  2013-06-08       Impact factor: 2.788

Review 2.  3-D Imaging and Simulation for Nephron Sparing Surgical Training.

Authors:  Hamed Ahmadi; Jen-Jane Liu
Journal:  Curr Urol Rep       Date:  2016-08       Impact factor: 3.092

3.  Human Cadaveric Artificial Lung Tumor-Mimic Training Model.

Authors:  Réka Székely; Ferenc Imre Suhai; Kinga Karlinger; Gábor Baksa; Bence Szabaczki; László Bárány; Gergely Pölöskei; Gergely Rácz; Ödön Wagner; Béla Merkely; Tamás Ruttkay
Journal:  Pathol Oncol Res       Date:  2021-04-26       Impact factor: 3.201

Review 4.  Simulation-based training in laparoscopic urology - Pros and cons.

Authors:  Abhishek Gajendra Singh
Journal:  Indian J Urol       Date:  2018 Oct-Dec

5.  Generation of a TP53-modified porcine cancer model by CRISPR/Cas9-mediated gene modification in porcine zygotes via electroporation.

Authors:  Fuminori Tanihara; Maki Hirata; Nhien Thi Nguyen; Quynh Anh Le; Takayuki Hirano; Tatsuya Takemoto; Michiko Nakai; Dai-Ichiro Fuchimoto; Takeshige Otoi
Journal:  PLoS One       Date:  2018-10-23       Impact factor: 3.240

  5 in total

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