BACKGROUND: Prostate cancer incidence and mortality rates vary widely among individuals of different ethnic/racial groups. We identified a relationship between a subset of genes and race/ethnicity using gene expression profiling. Estrogen receptor alpha (ERalpha) was selected for confirmation due to its plausible biological role in cancer susceptibility. METHODS: Quantitative polymerase chain reaction (Q-PCR) was used to verify gene expression results. Protein levels of ERalpha were determined by quantitative immunohistochemistry in a large-scale tissue microarray study (n = 183). RESULTS: ERalpha was significantly higher in stroma of Hispanic and Asian men than in Caucasian (P < 0.0001) and African American men (P < 0.0002), who are at higher risk for prostate cancer. In addition, large differences were seen in Q-PCR levels of ERalpha in prostate tissues of organ donors 16-29 years old who had no evidence of cancer. CONCLUSIONS: ERalpha exhibits variable expression in men of difference racial/ethnic background. Understanding the molecular basis for these differences may form the basis for prostate cancer prevention strategies with widespread public health impact. Copyright 2005 Wiley-Liss, Inc.
BACKGROUND:Prostate cancer incidence and mortality rates vary widely among individuals of different ethnic/racial groups. We identified a relationship between a subset of genes and race/ethnicity using gene expression profiling. Estrogen receptor alpha (ERalpha) was selected for confirmation due to its plausible biological role in cancer susceptibility. METHODS: Quantitative polymerase chain reaction (Q-PCR) was used to verify gene expression results. Protein levels of ERalpha were determined by quantitative immunohistochemistry in a large-scale tissue microarray study (n = 183). RESULTS:ERalpha was significantly higher in stroma of Hispanic and Asian men than in Caucasian (P < 0.0001) and African American men (P < 0.0002), who are at higher risk for prostate cancer. In addition, large differences were seen in Q-PCR levels of ERalpha in prostate tissues of organ donors 16-29 years old who had no evidence of cancer. CONCLUSIONS:ERalpha exhibits variable expression in men of difference racial/ethnic background. Understanding the molecular basis for these differences may form the basis for prostate cancer prevention strategies with widespread public health impact. Copyright 2005 Wiley-Liss, Inc.
Authors: Ying Huang; Sumit Isharwal; Alexander Haese; Felix K H Chun; Danil V Makarov; Ziding Feng; Misop Han; Elizabeth Humphreys; Jonathan I Epstein; Alan W Partin; Robert W Veltri Journal: BJU Int Date: 2010-09-28 Impact factor: 5.588
Authors: Garrett Daniels; Lan Lin Gellert; Jonathan Melamed; David Hatcher; Yirong Li; Jianjun Wei; Jinhua Wang; Peng Lee Journal: Am J Transl Res Date: 2014-01-15 Impact factor: 4.060
Authors: Olga A Timofeeva; Xueping Zhang; Habtom W Ressom; Rency S Varghese; Bhaskar V S Kallakury; Kan Wang; Youngmi Ji; Amrita Cheema; Mira Jung; Milton L Brown; Johng S Rhim; Anatoly Dritschilo Journal: Int J Oncol Date: 2009-10 Impact factor: 5.650
Authors: Pei-Hsuan Weng; Yi-Ling Huang; John H Page; Jen-Hau Chen; Jianfeng Xu; Stella Koutros; Sonja Berndt; Stephen Chanock; Meredith Yeager; John S Witte; Rosalind A Eeles; Douglas F Easton; David E Neal; Jenny Donovan; Freddie C Hamdy; Kenneth R Muir; Graham Giles; Gianluca Severi; Jeffrey R Smith; Carmela R Balistreri; Irene M Shui; Yen-Ching Chen Journal: PLoS One Date: 2014-10-31 Impact factor: 3.240
Authors: Emmanuel Nna; Jonathan Madukwe; Ejike Egbujo; Chris Obiorah; Charles Okolie; Godwin Echejoh; Amina Yahaya; James Adisa; Ijeoma Uzoma Journal: Med Princ Pract Date: 2012-10-13 Impact factor: 1.927