BACKGROUND: Since the Edmonton trial in 2000, increasing numbers of transplant centers have been implementing islet transplantation programs. Some institutions have elected to associate in multicenter networks, such as the Swiss-French GRAGIL (Groupe Rhin-Rhône-Alpes-Genève pour la Transplantation d'Ilots de Langerhans) consortium. METHODS: All pancreata offers to the University of Geneva Cell Isolation and Transplantation Center from within the network in 2002 and 2003 were reviewed. Islet preparations were attributed to the most suitable recipient on a centrally managed waiting list. All shipments were performed by ambulance in less than 5 hr. RESULTS: Over the period of study, 260 pancreata were offered, from a total of 1,304 cadaveric donors in the four allocation regions (20%). Fifty-two patients were on the waiting list at any time during this 2-year period. The percentage of organs offered varied in the range of 0.5% to 42%, depending on region of origin, with a correlation with number of patients on the waiting list in each region. Of these, 104 (40%) were accepted for processing. Ninety-two pancreata were actually processed, resulting in 42 islet preparations being transplanted. The number of international equivalents of transplanted preparations was 378,500+/-16,000 versus 165,400+/-15,400 (P<0.0001) for nontransplanted preparations. Total cold ischemia time was 6+/-0.3 hr for transplanted preparations versus 6.7+/-0.4 hr for nontransplanted preparations (not significant). CONCLUSIONS.: A high rate of pancreas offers, successful isolation, and islet transplantation can be achieved in multicenter networks such as GRAGIL. Such an approach can expand both the donor pool and the recipient population.
BACKGROUND: Since the Edmonton trial in 2000, increasing numbers of transplant centers have been implementing islet transplantation programs. Some institutions have elected to associate in multicenter networks, such as the Swiss-French GRAGIL (Groupe Rhin-Rhône-Alpes-Genève pour la Transplantation d'Ilots de Langerhans) consortium. METHODS: All pancreata offers to the University of Geneva Cell Isolation and Transplantation Center from within the network in 2002 and 2003 were reviewed. Islet preparations were attributed to the most suitable recipient on a centrally managed waiting list. All shipments were performed by ambulance in less than 5 hr. RESULTS: Over the period of study, 260 pancreata were offered, from a total of 1,304 cadaveric donors in the four allocation regions (20%). Fifty-two patients were on the waiting list at any time during this 2-year period. The percentage of organs offered varied in the range of 0.5% to 42%, depending on region of origin, with a correlation with number of patients on the waiting list in each region. Of these, 104 (40%) were accepted for processing. Ninety-two pancreata were actually processed, resulting in 42 islet preparations being transplanted. The number of international equivalents of transplanted preparations was 378,500+/-16,000 versus 165,400+/-15,400 (P<0.0001) for nontransplanted preparations. Total cold ischemia time was 6+/-0.3 hr for transplanted preparations versus 6.7+/-0.4 hr for nontransplanted preparations (not significant). CONCLUSIONS.: A high rate of pancreas offers, successful isolation, and islet transplantation can be achieved in multicenter networks such as GRAGIL. Such an approach can expand both the donor pool and the recipient population.
Authors: John S Kaddis; Matthew S Hanson; James Cravens; Dajun Qian; Barbara Olack; Martha Antler; Klearchos K Papas; Itzia Iglesias; Barbara Barbaro; Luis Fernandez; Alvin C Powers; Joyce C Niland Journal: Cell Transplant Date: 2012-08-10 Impact factor: 4.064
Authors: Klearchos K Papas; Theodore Karatzas; Thierry Berney; Thomas Minor; Paris Pappas; François Pattou; James Shaw; Christian Toso; Henk-Jan Schuurman Journal: Clin Transplant Date: 2013-01-18 Impact factor: 2.863
Authors: Appakalai N Balamurugan; Michael L Green; Andrew G Breite; Gopalakrishnan Loganathan; Joshua J Wilhelm; Benjamin Tweed; Lenka Vargova; Amber Lockridge; Manikya Kuriti; Michael G Hughes; Stuart K Williams; Bernhard J Hering; Francis E Dwulet; Robert C McCarthy Journal: Transplant Direct Date: 2015-12-23
Authors: Ali Aldibbiat; Guo Cai Huang; Min Zhao; Graham N Holliman; Linda Ferguson; Stephen Hughes; Ken Brigham; Julie Wardle; Rob Williams; Anne Dickinson; Steven A White; Paul R V Johnson; Derek Manas; Stephanie A Amiel; James A M Shaw Journal: Cell Med Date: 2011-12-09