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Literature DB >> 15879615

Mitochondrial antigens as targets of cellular and humoral auto-immunity in primary biliary cirrhosis.

Yasunori Ichiki¹, Carlo Selmi, Shinji Shimoda, Hiromi Ishibashi, Stuart C Gordon, M Eric Gershwin.

Abstract

Several factors point toward an auto-immune pathogenesis for primary biliary cirrhosis(PBC), mostly based on the presence of serum auto-antibodies to mitochondrial antigens(AMAs) and autoreactive T cells (both helper and cytotoxic). Interestingly, epitopes recognized by AMA and T-cell clones are located within overlapping areas of the antigens. Moreover,a role for an imbalance in cytokine pattern and for natural-killer lymphocytes has also been proposed. Despite several experimental reports, no clear evidence is available regarding the interaction of these factors leading to bile duct destruction. This article reviews the current reports regarding the auto-immune reaction against mitochondrial auto-antigens in PBC.

Entities: Disease

Mesh：

Substances：

Year: 2005 PMID： 15879615 DOI： 10.1385/CRIAI:28:2:083

Source DB: PubMed Journal: Clin Rev Allergy Immunol ISSN： 1080-0549 Impact factor: 8.667

54 in total

1. Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis.

Authors: Hiroto Kita; Shuji Matsumura; Xiao-Song He; Aftab A Ansari; Zhe-Xiong Lian; Judy Van de Water; Ross L Coppel; Marshall M Kaplan; M Eric Gershwin
Journal: J Clin Invest Date: 2002-05 Impact factor: 14.808

2. Expression of HLA-DR antigens on interlobular bile ducts in primary biliary cirrhosis and other hepatobiliary diseases: an immunohistochemical study.

Authors: Y Nakanuma; N Kono
Journal: Hum Pathol Date: 1991-05 Impact factor: 3.466

3. Class II MHC-bearing keratinocytes induce antigen-specific unresponsiveness in hapten-specific Th1 clones.

Authors: A A Gaspari; M K Jenkins; S I Katz
Journal: J Immunol Date: 1988-10-01 Impact factor: 5.422

4. Clonal analysis of liver-derived T cells of patients with primary biliary cirrhosis.

Authors: R M Hoffmann; G R Pape; U Spengler; E P Rieber; J Eisenburg; J Döhrmann; G Paumgartner; G Riethmüller
Journal: Clin Exp Immunol Date: 1989-05 Impact factor: 4.330

5. Bile duct epithelia as target cells in primary biliary cirrhosis and primary sclerosing cholangitis.

Authors: H P Dienes; A W Lohse; G Gerken; P Schirmacher; H Gallati; H F Löhr; K H Meyer zum Büschenfelde
Journal: Virchows Arch Date: 1997-08 Impact factor: 4.064

6. Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways.

Authors: A N Vallejo; M Schirmer; C M Weyand; J J Goronzy
Journal: J Immunol Date: 2000-12-01 Impact factor: 5.422

7. Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis.

Authors: Takashi Kamihira; Shinji Shimoda; Kenichi Harada; Akira Kawano; Mizuki Handa; Eishi Baba; Koichi Tsuneyama; Minoru Nakamura; Hiromi Ishibashi; Yasuni Nakanuma; M Eric Gershwin; Mine Harada
Journal: Gastroenterology Date: 2003-11 Impact factor: 22.682

8. Characterization of recombinant monoclonal IgA anti-PDC-E2 autoantibodies derived from patients with PBC.

Authors: Nobuyoshi Fukushima; Greg Nalbandian; Judy Van De Water; Kandra White; Aftab A Ansari; Patrick Leung; Thomas Kenny; Shizuo G Kamita; Bruce D Hammock; Ross L Coppel; Freida Stevenson; Hiromi Ishibashi; M Eric Gershwin
Journal: Hepatology Date: 2002-12 Impact factor: 17.425

9. Expression of co-stimulatory factor B7-2 on the intrahepatic bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis: an immunohistochemical study.

Authors: K Tsuneyama; K Harada; M Yasoshima; K Kaji; M E Gershwin; Y Nakanuma
Journal: J Pathol Date: 1998-10 Impact factor: 7.996

10. The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase.

Authors: J Van de Water; M E Gershwin; P Leung; A Ansari; R L Coppel
Journal: J Exp Med Date: 1988-06-01 Impact factor: 14.307

5 in total

Mitochondrial antigens as targets of cellular and humoral auto-immunity in primary biliary cirrhosis.

1. Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis.

2. Expression of HLA-DR antigens on interlobular bile ducts in primary biliary cirrhosis and other hepatobiliary diseases: an immunohistochemical study.

3. Class II MHC-bearing keratinocytes induce antigen-specific unresponsiveness in hapten-specific Th1 clones.

4. Clonal analysis of liver-derived T cells of patients with primary biliary cirrhosis.

5. Bile duct epithelia as target cells in primary biliary cirrhosis and primary sclerosing cholangitis.

6. Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways.

7. Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis.

8. Characterization of recombinant monoclonal IgA anti-PDC-E2 autoantibodies derived from patients with PBC.

9. Expression of co-stimulatory factor B7-2 on the intrahepatic bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis: an immunohistochemical study.

10. The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase.

Review 1. Cutting-edge issues in primary biliary cirrhosis.

Review 2. Advances in pharmacotherapy for primary biliary cirrhosis.

Review 3. Primary biliary cirrhosis and autoimmune hepatitis: apotopes and epitopes.

Review 4. Role of cholangiocytes in primary biliary cirrhosis.

5. Emperipolesis mediated by CD8⁺ T cells correlates with biliary epithelia cell injury in primary biliary cholangitis.