Literature DB >> 15879457

SDMinP: a program to control the family wise error rate using step-down minP adjusted P-values.

M Obreiter1, C Fischer, J Chang-Claude, L Beckmann.   

Abstract

SDMinP is an easy-to-use program for fast calculation of empirical and adjusted P-values for correlated and uncorrelated hypotheses in multiple testing experiments. It is based on the Free Step-Down Resampling Method for controlling the family wise error rate, and implements a variation of an efficient algorithm, which reduces the originally required re-sampling effort considerably and makes the method computationally feasible. The program is independent of the underlying test statistic and works with provided observed and permutation test statistics.

Mesh:

Year:  2005        PMID: 15879457     DOI: 10.1093/bioinformatics/bti480

Source DB:  PubMed          Journal:  Bioinformatics        ISSN: 1367-4803            Impact factor:   6.937


  4 in total

1.  AMBIENCE: a novel approach and efficient algorithm for identifying informative genetic and environmental associations with complex phenotypes.

Authors:  Pritam Chanda; Lara Sucheston; Aidong Zhang; Daniel Brazeau; Jo L Freudenheim; Christine Ambrosone; Murali Ramanathan
Journal:  Genetics       Date:  2008-09-09       Impact factor: 4.562

2.  The interaction index, a novel information-theoretic metric for prioritizing interacting genetic variations and environmental factors.

Authors:  Pritam Chanda; Lara Sucheston; Aidong Zhang; Murali Ramanathan
Journal:  Eur J Hum Genet       Date:  2009-03-18       Impact factor: 4.246

3.  Haplotype-sharing analysis using Mantel statistics for combined genetic effects.

Authors:  Lars Beckmann; Christine Fischer; Markus Obreiter; Michael Rabes; Jenny Chang-Claude
Journal:  BMC Genet       Date:  2005-12-30       Impact factor: 2.797

4.  Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritis.

Authors:  Astrid Dempfle; Rebecca Hein; Lars Beckmann; André Scherag; Thuy Trang Nguyen; Helmut Schäfer; Jenny Chang-Claude
Journal:  BMC Proc       Date:  2007-12-18
  4 in total

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