OBJECTIVE: To investigate the contribution of polymorphisms in multiple candidate genes to cardiovascular disease (CVD) risk in a large cohort of patients with heterozygous familial hypercholesterolemia (FH). METHODS AND RESULTS: We genotyped 1940 FH patients for 65 polymorphisms in 36 candidate genes. During 91.451 person-years, 643 (33.1%) patients had at least 1 cardiovascular event. Multifactorial Cox survival analysis revealed that the G20210A polymorphism in the prothrombin gene was strongly associated with a significantly increased CVD risk (GA versus GG; P<0.001). CONCLUSIONS: In a large cohort of FH patients, we found that the G20210A polymorphism in the prothrombin gene is strongly associated with CVD risk. Our results constitute a step forward in the unraveling of the hereditary propensity toward CVD in FH and might lead to better risk stratification and hence to more tailored therapy for CVD prevention.
OBJECTIVE: To investigate the contribution of polymorphisms in multiple candidate genes to cardiovascular disease (CVD) risk in a large cohort of patients with heterozygous familial hypercholesterolemia (FH). METHODS AND RESULTS: We genotyped 1940 FHpatients for 65 polymorphisms in 36 candidate genes. During 91.451 person-years, 643 (33.1%) patients had at least 1 cardiovascular event. Multifactorial Cox survival analysis revealed that the G20210A polymorphism in the prothrombin gene was strongly associated with a significantly increased CVD risk (GA versus GG; P<0.001). CONCLUSIONS: In a large cohort of FHpatients, we found that the G20210A polymorphism in the prothrombin gene is strongly associated with CVD risk. Our results constitute a step forward in the unraveling of the hereditary propensity toward CVD in FH and might lead to better risk stratification and hence to more tailored therapy for CVD prevention.
Authors: Jeroen B van der Net; Daniëlla M Oosterveer; Jorie Versmissen; Joep C Defesche; Mojgan Yazdanpanah; Bradley E Aouizerat; Ewout W Steyerberg; Mary J Malloy; Clive R Pullinger; John J P Kastelein; John P Kane; Eric J G Sijbrands Journal: Eur Heart J Date: 2008-07-03 Impact factor: 29.983
Authors: Juan Criado-García; Francisco Fuentes; Cristina Cruz-Teno; Antonio García-Rios; Anabel Jiménez-Morales; Javier Delgado-Lista; Pedro Mata; Rodrigo Alonso; José López-Miranda; Francisco Pérez-Jiménez Journal: Lipids Health Dis Date: 2011-04-09 Impact factor: 3.876
Authors: Erik P A van Iperen; Suthesh Sivapalaratnam; S Matthijs Boekholdt; G Kees Hovingh; Stephanie Maiwald; Michael W Tanck; Nicole Soranzo; Jonathan C Stephens; Jennifer G Sambrook; Marcel Levi; Willem H Ouwehand; John Jp Kastelein; Mieke D Trip; Aeilko H Zwinderman Journal: Eur J Hum Genet Date: 2013-11-13 Impact factor: 4.246
Authors: David M Diamond; Abdullah A Alabdulgader; Michel de Lorgeril; Zoe Harcombe; Malcolm Kendrick; Aseem Malhotra; Blair O'Neill; Uffe Ravnskov; Sherif Sultan; Jeff S Volek Journal: BMJ Evid Based Med Date: 2020-07-05