Literature DB >> 15879033

Multiple autoantigen mimotopes of infectious agents induce autoimmune arthritis and uveitis in lewis rats.

Gerhild Wildner1, Maria Diedrichs-Moehring.   

Abstract

We found multimolecular antigenic mimicry of arthritogenic autoantigens and peptides from several other "self" or foreign antigens sharing amino acid sequence homologies. Many of these new mimotopes induced arthritis and/or uveitis upon immunization in Lewis rats, indicating a role for multiple antigens in the initiation of a certain autoimmune disease.

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Year:  2005        PMID： 15879033      PMCID： PMC1112081          DOI： 10.1128/CDLI.12.5.677-679.2005

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  15 in total

1.  Cellular immune response to Klebsiella pneumoniae antigens in patients with HLA-B27+ ankylosing spondylitis.

Authors:  M L Domínguez-López; M E Cancino-Díaz; L Jiménez-Zamudio; J Granados-Arreola; R Burgos-Vargas; E García-Latorre
Journal:  J Rheumatol       Date:  2000-06       Impact factor: 4.666

2.  The peptide binding specificity of the MHC class II I-A molecule of the Lewis rat, RT1.BI.

Authors:  B Reizis; F Mor; M Eisenstein; H Schild; S Stefanoviç; H G Rammensee; I R Cohen
Journal:  Int Immunol       Date:  1996-12       Impact factor: 4.823

3.  Evidence for the presence of peroxisome proliferator-activated receptor (PPAR) alpha and gamma and retinoid Z receptor in cartilage. PPARgamma activation modulates the effects of interleukin-1beta on rat chondrocytes.

Authors:  K Bordji; J P Grillasca; J N Gouze; J Magdalou; H Schohn; J M Keller; A Bianchi; M Dauça; P Netter; B Terlain
Journal:  J Biol Chem       Date:  2000-04-21       Impact factor: 5.157

4.  Orally induced, peptide-specific gamma/delta TCR+ cells suppress experimental autoimmune uveitis.

Authors:  G Wildner; T Hünig; S R Thurau
Journal:  Eur J Immunol       Date:  1996-09       Impact factor: 5.532

5.  Autoimmune uveitis induced by molecular mimicry of peptides from rotavirus, bovine casein and retinal S-antigen.

Authors:  Gerhild Wildner; Maria Diedrichs-Möhring
Journal:  Eur J Immunol       Date:  2003-09       Impact factor: 5.532

6.  Human S-antigen: presence of multiple immunogenic and immunopathogenic sites in the Lewis rat.

Authors:  M D de Smet; G Bitar; F G Roberge; I Gery; R B Nussenblatt
Journal:  J Autoimmun       Date:  1993-10       Impact factor: 7.094

7.  HLA-B27-derived peptides as autoantigens for T lymphocytes in ankylosing spondylitis.

Authors:  E Märker-Hermann; K H Meyer zum Büschenfelde; G Wildner
Journal:  Arthritis Rheum       Date:  1997-11

8.  Specific activation of the nuclear receptors PPARgamma and RORA by the antidiabetic thiazolidinedione BRL 49653 and the antiarthritic thiazolidinedione derivative CGP 52608.

Authors:  I Wiesenberg; M Chiesi; M Missbach; C Spanka; W Pignat; C Carlberg
Journal:  Mol Pharmacol       Date:  1998-06       Impact factor: 4.436

9.  Cross-reactivity between an HLA-B27-derived peptide and a retinal autoantigen peptide: a clue to major histocompatibility complex association with autoimmune disease.

Authors:  G Wildner; S R Thurau
Journal:  Eur J Immunol       Date:  1994-11       Impact factor: 5.532

10.  Thiazolidine diones, specific ligands of the nuclear receptor retinoid Z receptor/retinoid acid receptor-related orphan receptor alpha with potent antiarthritic activity.

Authors:  M Missbach; B Jagher; I Sigg; S Nayeri; C Carlberg; I Wiesenberg
Journal:  J Biol Chem       Date:  1996-06-07       Impact factor: 5.157
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  2 in total

Review 1.  Interplay between innate and adaptive immunity in the development of non-infectious uveitis.

Authors:  François Willermain; James T Rosenbaum; Bahram Bodaghi; Holly L Rosenzweig; Sarah Childers; Travis Behrend; Gerhild Wildner; Andrew D Dick
Journal:  Prog Retin Eye Res       Date:  2011-11-22       Impact factor: 21.198

Review 2.  A look at autoimmunity and inflammation in the eye.

Authors:  Rachel R Caspi
Journal:  J Clin Invest       Date:  2010-09-01       Impact factor: 14.808
  2 in total

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