Literature DB >> 15879032

Detection by radioligand assay of antibodies against Borna disease virus in patients with various psychiatric disorders.

Hidenori Matsunaga1, Susumu Tanaka, Fuyoko Sasao, Yoshii Nishino, Masatoshi Takeda, Keizo Tomonaga, Kazuyoshi Ikuta, Nobuyuki Amino.   

Abstract

Using a radioligand assay, which preserves the natural form of the antigen, antibodies against Borna disease virus nucleoprotein and phosphoprotein were detected in 11 and 19 sera of 171 psychiatric patients, respectively. Compared with results by Western blotting, three and nine sera were concordantly positive, respectively. The four sera showing the highest levels of antibodies by radioligand assay were all negative by Western blotting; however, dilution and inhibition tests supported the positive results. Our results suggest the importance of conformational structure to detect human anti-Borna disease virus antibodies.

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Year:  2005        PMID： 15879032      PMCID： PMC1112074          DOI： 10.1128/CDLI.12.5.671-676.2005

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  19 in total

1.  Borna disease virus proteins in cerebrospinal fluid of patients with recurrent depression and multiple sclerosis.

Authors:  M Deuschle; L Bode; I Heuser; J Schmider; H Ludwig
Journal:  Lancet       Date:  1998-12-05       Impact factor: 79.321

2.  Isolation of Borna disease virus from human brain tissue.

Authors:  Y Nakamura; H Takahashi; Y Shoya; T Nakaya; M Watanabe; K Tomonaga; K Iwahashi; K Ameno; N Momiyama; H Taniyama; T Sata; T Kurata; J C de la Torre; K Ikuta
Journal:  J Virol       Date:  2000-05       Impact factor: 5.103

3.  A reverse-type sandwich enzyme-linked immunosorbent assay for detecting antibodies to Borna disease virus.

Authors:  T Horimoto; H Takahashi; M Sakaguchi; K Horikoshi; S Iritani; H Kazamatsuri; K Ikeda; M Tashiro
Journal:  J Clin Microbiol       Date:  1997-07       Impact factor: 5.948

4.  Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers.

Authors:  C H Chen; Y L Chiu; C K Shaw; M T Tsai; A L Hwang; K J Hsiao
Journal:  Mol Psychiatry       Date:  1999-11       Impact factor: 15.992

Review 5.  Borna disease virus--does it infect humans and cause psychiatric disorders?

Authors:  K Lieb; P Staeheli
Journal:  J Clin Virol       Date:  2001-05       Impact factor: 3.168

Review 6.  Borna disease virus: a mystery as an emerging zoonotic pathogen.

Authors:  J A Richt; R Rott
Journal:  Vet J       Date:  2001-01       Impact factor: 2.688

7.  Investigations of cerebrospinal fluid in Borna disease virus seropositive psychiatric patients.

Authors:  K Bechter; S Herzog; W Behr; R Schüttler
Journal:  Eur Psychiatry       Date:  1995       Impact factor: 5.361

8.  Detection of Borna disease virus-reactive antibodies from patients with affective disorders by western immunoblot technique.

Authors:  Z F Fu; J D Amsterdam; M Kao; V Shankar; H Koprowski; B Dietzschold
Journal:  J Affect Disord       Date:  1993-01       Impact factor: 4.839

9.  Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders.

Authors:  R Rott; S Herzog; B Fleischer; A Winokur; J Amsterdam; W Dyson; H Koprowski
Journal:  Science       Date:  1985-05-10       Impact factor: 47.728

10.  Borna disease virus and schizophrenia.

Authors:  R W Waltrip; R W Buchanan; A Summerfelt; A Breier; W T Carpenter; N L Bryant; S A Rubin; K M Carbone
Journal:  Psychiatry Res       Date:  1995-01-31       Impact factor: 3.222
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