Literature DB >> 15878841

Application of bone morphogenetic proteins in spinal fusion.

Munish C Gupta1, Safdar N Khan.   

Abstract

We are now entering an exciting new era in spinal surgery where the inherent osteoinductive capacity of the body has been harnessed for bone formation for therapeutic purposes. Recombinant bone morphogenetic proteins have been extensively studied in both the pre-clinical and clinical arena for spinal fusion with considerable success. The challenges facing spine surgeons now is the development of site-specific carriers and optimal doses for these growth factors. This review highlights the recent advances in this regard.

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Year:  2005        PMID: 15878841     DOI: 10.1016/j.cytogfr.2005.02.004

Source DB:  PubMed          Journal:  Cytokine Growth Factor Rev        ISSN: 1359-6101            Impact factor:   7.638


  4 in total

1.  BMP2-induced inflammation can be suppressed by the osteoinductive growth factor NELL-1.

Authors:  Jia Shen; Aaron W James; Janette N Zara; Greg Asatrian; Kevork Khadarian; James B Zhang; Stephanie Ho; Hyun Ju Kim; Kang Ting; Chia Soo
Journal:  Tissue Eng Part A       Date:  2013-07-17       Impact factor: 3.845

2.  Controversy of physiological vs. pharmacological effects of BMP signaling: Constitutive activation of BMP type IA receptor-dependent signaling in osteoblast lineage enhances bone formation and resorption, not affecting net bone mass.

Authors:  Nobuhiro Kamiya; Phimon Atsawasuwan; Danese M Joiner; Erik I Waldorff; Steve Goldstein; Mitsuo Yamauchi; Yuji Mishina
Journal:  Bone       Date:  2020-06-27       Impact factor: 4.398

3.  Accelerated postero-lateral spinal fusion by collagen scaffolds modified with engineered collagen-binding human bone morphogenetic protein-2 in rats.

Authors:  Xinglong Han; Wen Zhang; Jun Gu; Huan Zhao; Li Ni; Jiajun Han; Yun Zhou; Yannan Gu; Xuesong Zhu; Jie Sun; Xianglin Hou; Huilin Yang; Jianwu Dai; Qin Shi
Journal:  PLoS One       Date:  2014-05-28       Impact factor: 3.240

4.  Material-driven fibronectin and vitronectin assembly enhances BMP-2 presentation and osteogenesis.

Authors:  Yinbo Xiao; Hannah Donnelly; Mark Sprott; Jiajun Luo; Vineetha Jayawarna; Leandro Lemgruber; P Monica Tsimbouri; R M Dominic Meek; Manuel Salmeron-Sanchez; Matthew J Dalby
Journal:  Mater Today Bio       Date:  2022-07-19
  4 in total

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