| Literature DB >> 15878791 |
John Jia-En Chua1, Raghavan Bhuvanakantham, Vincent Tak-Kwong Chow, Mah-Lee Ng.
Abstract
A combination of yeast two-hybrid library screening, co-immunoprecipitation and immunofluorescence microscopy demonstrated that dengue-2 virus non-structural 1 (NS1) protein can interact with an N-terminally truncated form of human STAT3beta (DeltaN40-STAT3beta) protein. The NS1 protein interacted with the activated STAT3beta protein in vesicle-like structures in the cell cytoplasm. In addition, transfection of dendritic cells with plasmid expressing NS1 protein also resulted in significant induction of tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6). Since the STAT3beta protein is an acute-phase response factor, its interaction with NS1 protein may influence the pathological changes observed in dengue fever, dengue hemorrhagic fever and dengue shock syndrome.Entities:
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Year: 2005 PMID： 15878791 DOI： 10.1016/j.virusres.2005.03.025
Source DB: PubMed Journal: Virus Res ISSN： 0168-1702 Impact factor: 3.303