| Literature DB >> 15878749 |
S Jefferies1, Z Kote-Jarai, D Goldgar, R Houlston, M-J Frazer-Williams, R A'Hern, R Eeles, J Henk, M Gore, P Rhys-Evans, D Archer, K Bishop, E Solomon, S Hodgson, M McGurk, J Hibbert, M O'Connell, M Partridge, E Chevretton, F Calman, M Saunders, K Shotton, A Brown, S Whittaker, W Foulkes.
Abstract
We investigated the association between genetic polymorphisms in GPX1 gene amongst patients who had index squamous cell carcinoma (SCCHN) and a second primary tumour (SPT) after a primary SCCHN in a case-control study. GPX1 genotypes were determined for 61 patients with SPT and for 259 control subjects by a PCR technique using a fluorescent-labelled primer. Analysis was by an ABI automated fluorescent sequencer. The associations between specific genotypes and the development of SPT were examined by logistic regression. A significant difference was found between the control group and the SPT cases in allele frequencies of GPX1 ALA( *)6 and ALA( *)7 (p(trend)=0.04). These results suggest that polymorphisms in the GPX1 gene may be a marker for SPT development and further studies are indicated.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15878749 DOI： 10.1016/j.oraloncology.2004.09.012
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337