| Literature DB >> 15878278 |
Pei-Wen Hsieh1, Tsong-Long Hwang, Chin-Chung Wu, Fang-Rong Chang, Tsai-Wei Wang, Yang-Chang Wu.
Abstract
A series of 2,8-disubstituted benzoxazinones were synthesized and subjected to anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Among them, 2-(2'-substituted-phenyl)-benzoxazinones exhibited significant inhibitory effect to target assays. Additionally, all of them were more potent than aspirin on AA-induced platelet aggregation, and these suggested that 2-(2'-substituted-phenyl)-benzoxazinones also possess aspirin-like activity. On the other hand, the compounds 6 and 16 showed inhibitory effects on neutrophil elastase release and superoxide generation.Entities:
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Year: 2005 PMID： 15878278 DOI： 10.1016/j.bmcl.2005.03.104
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823