Literature DB >> 15878103

Effectiveness and toxicity of single-fraction radiotherapy with 1 x 8 Gy for metastatic spinal cord compression.

Dirk Rades1, Lukas J A Stalpers, Maarten C C M Hulshof, Oliver Zschenker, Winfried Alberti, Caro C E Koning.   

Abstract

Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1 x 8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors (> or =12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.

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Year:  2005        PMID: 15878103     DOI: 10.1016/j.radonc.2004.12.013

Source DB:  PubMed          Journal:  Radiother Oncol        ISSN: 0167-8140            Impact factor:   6.280


  4 in total

1.  Spinal radiosurgery: a neurosurgical perspective.

Authors:  Mark H Bilsky; Lilyana Angelov; Jack Rock; Jason Weaver; Jason Sheehan; Laurence Rhines; Syed Azeem; Peter Gerszten
Journal:  J Radiosurg SBRT       Date:  2011

2.  Stereotactic body radiosurgery for spinal metastatic disease: an evidence-based review.

Authors:  William A Hall; Liza J Stapleford; Costas G Hadjipanayis; Walter J Curran; Ian Crocker; Hui-Kuo G Shu
Journal:  Int J Surg Oncol       Date:  2011-07-10

3.  What Is the Value of Surgical Intervention for Sacral Metastases?

Authors:  Zhiye Du; Wei Guo; Rongli Yang; Xiaodong Tang; Tao Ji; Dasen Li
Journal:  PLoS One       Date:  2016-12-19       Impact factor: 3.240

4.  Non-inferiority randomised phase 3 trial comparing two radiation schedules (single vs. five fractions) in malignant spinal cord compression.

Authors:  Pierre G Thirion; Mary T Dunne; Paul J Kelly; Aileen Flavin; Joe M O'Sullivan; Dayle Hacking; Wojciech Sasiadek; Cormac Small; Maeve M Pomeroy; Joseph Martin; Orla McArdle; Imelda Parker; Lydia S O'Sullivan; Aoife M Shannon; Angela Clayton-Lea; Conor D Collins; Michael R Stevenson; Alberto Alvarez-Iglesias; John G Armstrong; Michael Moriarty
Journal:  Br J Cancer       Date:  2020-03-11       Impact factor: 7.640

  4 in total

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