| Literature DB >> 15876535 |
Robert E McDevitt1, Michael S Malamas, Eric S Manas, Rayomand J Unwalla, Zhang B Xu, Chris P Miller, Heather A Harris.
Abstract
The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERbeta and ERalpha are described. Several compounds exhibited high potency and moderate selectivity for the ERbeta receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.Entities:
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Year: 2005 PMID： 15876535 DOI： 10.1016/j.bmcl.2005.04.013
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823