| Literature DB >> 15876534 |
Dimitris Anagnostopoulos1, Chryssostomos Chatgilialoglu, Carla Ferreri, Abdelouahid Samadi, Athanassia Siafaka-Kapadai.
Abstract
A simple and high-yielding method to convert natural all-cis PUFA derivatives to the corresponding all-trans geometrical isomers is described. The method is based on the thiyl radical-catalyzed cis-trans isomerization. The all-trans isomer of arachidonic acid was found to cause rabbit platelet aggregation at concentrations higher than 0.1 mM and inhibition of PAF-induced platelet aggregation in a concentration dependent manner with an IC(50) in the micromolar range.Entities:
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Year: 2005 PMID： 15876534 DOI： 10.1016/j.bmcl.2005.03.109
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823