| Literature DB >> 15876531 |
Neil J Press1, Roger J Taylor, Joseph D Fullerton, Pamela Tranter, Clive McCarthy, Thomas H Keller, Lyndon Brown, Robert Cheung, Julie Christie, Sandra Haberthuer, Julia D I Hatto, Mark Keenan, Mark K Mercer, Nicola E Press, Helene Sahri, Andrew R Tuffnell, Morris Tweed, John R Fozard.
Abstract
The synthesis and SAR of 5-heterocycle-substituted aminothiazole adenosine receptor antagonists is described. Several compounds show high affinity and selectivity for the A2B and A3 receptors. One compound (5f) shows good ADME properties in the rat and as such may be an important new compound in testing the current hypotheses proposing a therapeutic role for a dual A2B/A3 antagonist in allergic diseases.Entities:
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Year: 2005 PMID： 15876531 DOI： 10.1016/j.bmcl.2005.04.021
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823