| Literature DB >> 15876049 |
M Carmen Carreño1, Renaud Des Mazery, Antonio Urbano, Françoise Colobert, Guy Solladié.
Abstract
The asymmetric synthesis of both enantiomers of cis-lauthisan (3) is achieved in only six steps from diethyl pimelate (4), the key steps being the diastereodivergent reduction of beta-ketosulfoxide 7 and the highly cis-stereoselective Et(3)SiH/TMSOTf-promoted reductive cyclization of enantiopure hydroxy sulfinyl ketones (S)-14 and (R)-14.Entities:
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Year: 2005 PMID： 15876049 DOI： 10.1021/ol050620a
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005