| Literature DB >> 15875451 |
Allan D Angerio1, Dominick Bufalino, Melissa Bresnick, Christine Bell, Sarah Brill.
Abstract
Inflammatory bowel disease (IBD) appears to be an inappropriate response to an antigen that leads to chronic inflammation rather than repair. This review looks at the role of endothelin-1 (ET-1) as a proinflammatory agent in IBD. ET-1 antagonists in animal models reduce the incidence and severity of IBD. These antagonists may be useful for treatment of IBD in humans.Entities:
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Year: 2005 PMID： 15875451 DOI： 10.1097/00002727-200504000-00013
Source DB: PubMed Journal: Crit Care Nurs Q ISSN： 0887-9303