| Literature DB >> 1587349 |
M Portier1, D Lees, E Caron, M Jourdan, J M Boiron, R Bataille, B Klein.
Abstract
Myeloma cells absolutely require interleukin-6 (IL-6) for growing in vivo in patients with multiple myeloma and exogenous IL-6-dependent myeloma cell lines have been reproducibly obtained. In this study we show a dramatic up-regulation of the IL-6 receptor (gp80 chain) gene expression in myeloma cell lines following the removal of exogenous IL-6. Such a regulation was also known to occur in IL-6-deprived myeloma cells in vivo in three patients who were treated with optimal doses of anti-IL-6 monoclonal antibodies. The direct effect of IL-6 on IL-6 receptor gene expression in myeloma cells was further confirmed by adding IL-6 to an autonomously growing myeloma cell line.Entities:
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Year: 1992 PMID： 1587349 DOI： 10.1016/0014-5793(92)80278-o
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124