Literature DB >> 15871693

Piezo- and solenoid valve-based liquid dispensing for miniaturized assays.

Walter D Niles1, Peter J Coassin.   

Abstract

Miniaturization of biological assays requires dispensing liquids in the submicroliter range of volumes. Accuracy and reproducibility of dispensing this range depend on both the dispenser and the receptacle in which the assay is constructed. Miniaturization technologies developed by Aurora Discovery, Inc. (San Diego, CA) include high-density multiwell plates for assay samples and reagent storage, as well as piezo-based and solenoid valve-based liquid dispensers. Some basic principles of small-volume dispensing by jetting are described to provide context for dispenser design and function. Performance of the latest instruments incorporating these dispensing devices is presented.

Mesh：

Year:  2005        PMID： 15871693     DOI： 10.1089/adt.2005.3.189

Source DB:  PubMed          Journal:  Assay Drug Dev Technol        ISSN： 1540-658X            Impact factor:   1.738


  14 in total

1.  A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction.

Authors:  Adam J Kimple; Adam Yasgar; Mark Hughes; Ajit Jadhav; Francis S Willard; Robin E Muller; Christopher P Austin; James Inglese; Gordon C Ibeanu; David P Siderovski; Anton Simeonov
Journal:  Comb Chem High Throughput Screen       Date:  2008-06       Impact factor: 1.339

2.  Comparison of bioluminescent kinase assays using substrate depletion and product formation.

Authors:  Cordelle Tanega; Min Shen; Bryan T Mott; Craig J Thomas; Ryan MacArthur; James Inglese; Douglas S Auld
Journal:  Assay Drug Dev Technol       Date:  2009-12       Impact factor: 1.738

3.  A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries.

Authors:  Ronald L Johnson; Ruili Huang; Ajit Jadhav; Noel Southall; Jennifer Wichterman; Ryan MacArthur; Menghang Xia; Kun Bi; John Printen; Christopher P Austin; James Inglese
Journal:  Mol Biosyst       Date:  2009-06-19

4.  Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Authors:  Matthew B Boxer; Jian-kang Jiang; Matthew G Vander Heiden; Min Shen; Amanda P Skoumbourdis; Noel Southall; Henrike Veith; William Leister; Christopher P Austin; Hee Won Park; James Inglese; Lewis C Cantley; Douglas S Auld; Craig J Thomas
Journal:  J Med Chem       Date:  2010-02-11       Impact factor: 7.446

5.  Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction.

Authors:  Anton Simeonov; Adam Yasgar; Ajit Jadhav; G L Lokesh; Carleen Klumpp; Sam Michael; Christopher P Austin; Amarnath Natarajan; James Inglese
Journal:  Anal Biochem       Date:  2007-12-05       Impact factor: 3.365

6.  A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS.

Authors:  Ping Jun Zhu; Wei Zheng; Douglas S Auld; Ajit Jadhav; Ryan Macarthur; Keith R Olson; Kun Peng; Hyna Dotimas; Christopher P Austin; James Inglese
Journal:  Comb Chem High Throughput Screen       Date:  2008-08       Impact factor: 1.339

7.  Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.

Authors:  Christophe Marchand; Wendy A Lea; Ajit Jadhav; Thomas S Dexheimer; Christopher P Austin; James Inglese; Yves Pommier; Anton Simeonov
Journal:  Mol Cancer Ther       Date:  2009-01       Impact factor: 6.261

8.  Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.

Authors:  Sunita J Shukla; Dac-Trung Nguyen; Ryan Macarthur; Anton Simeonov; William J Frazee; Tina M Hallis; Bryan D Marks; Upinder Singh; Hildegard C Eliason; John Printen; Christopher P Austin; James Inglese; Douglas S Auld
Journal:  Assay Drug Dev Technol       Date:  2009-04       Impact factor: 1.738

9.  Inkjet metrology: high-accuracy mass measurements of microdroplets produced by a drop-on-demand dispenser.

Authors:  R Michael Verkouteren; Jennifer R Verkouteren
Journal:  Anal Chem       Date:  2009-10-15       Impact factor: 6.986

10.  Identification of small molecule compounds that inhibit the HIF-1 signaling pathway.

Authors:  Menghang Xia; Kun Bi; Ruili Huang; Ming-Hsuang Cho; Srilatha Sakamuru; Susanne C Miller; Hua Li; Yi Sun; John Printen; Christopher P Austin; James Inglese
Journal:  Mol Cancer       Date:  2009-12-09       Impact factor: 27.401
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