BACKGROUND: The LRIG-1 gene (formerly LIG-1) encodes a type 1 transmembrane glycoprotein with an extracellular region of 15 leucine-rich repeats and 3 immunoglobulin-like domains. LRIG-1 interacts with ErbB receptors, down-regulating the downstream signals. Because ErbB signaling is disrupted in cutaneous squamous cell carcinoma (SCC), we examined LRIG-1 expression in cutaneous SCC. OBJECTIVE: To analyze the differential expression of LRIG-1 and to investigate whether LRIG-1 is useful as a prognostic indicator in SCC of the skin. METHODS: LRIG-1 expression in 38 cases of cutaneous SCC patients was examined by immunohistochemistry. RESULTS: LRIG-1 expression was highest in well-differentiated lesions of cutaneous SCC. The cases studied here were categorized into 23 cases (60.5%) of high expression and 15 cases (39.5%) of low expression of LRIG-1. There was a significant correlation (p = .000018) of LRIG-1 expression intensity of tumor cells with histologic differentiation of SCC. Furthermore, we found a significant inverse correlation with metastatic rate (p = .02). When the overall survival of SCC patients was statistically compared between high and low LRIG-1 expression groups, a significant survival benefit for the patients in the former group was found (p = .03). CONCLUSION: LRIG-1 expression is an excellent candidate for a prognostic indicator of cutaneous SCC.
BACKGROUND: The LRIG-1 gene (formerly LIG-1) encodes a type 1 transmembrane glycoprotein with an extracellular region of 15 leucine-rich repeats and 3 immunoglobulin-like domains. LRIG-1 interacts with ErbB receptors, down-regulating the downstream signals. Because ErbB signaling is disrupted in cutaneous squamous cell carcinoma (SCC), we examined LRIG-1 expression in cutaneous SCC. OBJECTIVE: To analyze the differential expression of LRIG-1 and to investigate whether LRIG-1 is useful as a prognostic indicator in SCC of the skin. METHODS:LRIG-1 expression in 38 cases of cutaneous SCC patients was examined by immunohistochemistry. RESULTS:LRIG-1 expression was highest in well-differentiated lesions of cutaneous SCC. The cases studied here were categorized into 23 cases (60.5%) of high expression and 15 cases (39.5%) of low expression of LRIG-1. There was a significant correlation (p = .000018) of LRIG-1 expression intensity of tumor cells with histologic differentiation of SCC. Furthermore, we found a significant inverse correlation with metastatic rate (p = .02). When the overall survival of SCC patients was statistically compared between high and low LRIG-1 expression groups, a significant survival benefit for the patients in the former group was found (p = .03). CONCLUSION:LRIG-1 expression is an excellent candidate for a prognostic indicator of cutaneous SCC.
Authors: Oghenekevwe M Gbenedio; Caroline Bonnans; Delphine Grun; Chih-Yang Wang; Ace J Hatch; Michelle R Mahoney; David Barras; Mary Matli; Yi Miao; K Christopher Garcia; Sabine Tejpar; Mauro Delorenzi; Alan P Venook; Andrew B Nixon; Robert S Warren; Jeroen P Roose; Philippe Depeille Journal: JCI Insight Date: 2019-06-25
Authors: Thomas Tilling; Ewa Wladykowski; Antonio Virgilio Failla; Pia Houdek; Johanna M Brandner; Ingrid Moll Journal: Histochem Cell Biol Date: 2013-11-30 Impact factor: 4.304