Literature DB >> 15871024

[Stem cell-based therapies for retinal disorders].

U Bartsch1, S J Linke, B Petrowitz.   

Abstract

In the context of cell-based therapies for hereditary retinal dystrophies and other retinal disorders, interest has focussed on the therapeutic potential of embryonic and tissue-specific stem cells. Stem cells are characterised by their capacity for self-renewal and by their multipotentiality. Because of these properties, they can be expanded in vitro and eventually differentiated into "desired" specialized cell types. Stem cells are not only candidate cells for the development of cell replacement strategies, but are also interesting cells for the establishment of ex vivo gene therapies. Here, we discuss recent experimental work performed to evaluate the therapeutic potential of embryonic, mesenchymal, hematopoietic, neural and retinal stem cells for the treatment of inherited retinal dystrophies and other retinal diseases.

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Year:  2005        PMID: 15871024     DOI: 10.1007/s00347-005-1188-4

Source DB:  PubMed          Journal:  Ophthalmologe        ISSN: 0941-293X            Impact factor:   1.059


  62 in total

Review 1.  Will retinal implants restore vision?

Authors:  Eberhart Zrenner
Journal:  Science       Date:  2002-02-08       Impact factor: 47.728

Review 2.  Retinal transplantation: progress and problems in clinical application.

Authors:  R D Lund; S J Ono; D J Keegan; J M Lawrence
Journal:  J Leukoc Biol       Date:  2003-08       Impact factor: 4.962

3.  Directed differentiation of embryonic stem cells into motor neurons.

Authors:  Hynek Wichterle; Ivo Lieberam; Jeffery A Porter; Thomas M Jessell
Journal:  Cell       Date:  2002-08-09       Impact factor: 41.582

4.  Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes.

Authors:  Manuel Alvarez-Dolado; Ricardo Pardal; Jose M Garcia-Verdugo; John R Fike; Hyun O Lee; Klaus Pfeffer; Carlos Lois; Sean J Morrison; Arturo Alvarez-Buylla
Journal:  Nature       Date:  2003-10-12       Impact factor: 49.962

5.  Subretinally transplanted embryonic stem cells rescue photoreceptor cells from degeneration in the RCS rats.

Authors:  U Schraermeyer; G Thumann; T Luther; N Kociok; S Armhold; K Kruttwig; C Andressen; K Addicks; K U Bartz-Schmidt
Journal:  Cell Transplant       Date:  2001       Impact factor: 4.064

6.  Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy.

Authors:  R R Ali; G M Sarra; C Stephens; M D Alwis; J W Bainbridge; P M Munro; S Fauser; M B Reichel; C Kinnon; D M Hunt; S S Bhattacharya; A J Thrasher
Journal:  Nat Genet       Date:  2000-07       Impact factor: 38.330

7.  Preservation of visual responsiveness in the superior colliculus of RCS rats after retinal pigment epithelium cell transplantation.

Authors:  Y Sauvé; S V Girman; S Wang; D J Keegan; R D Lund
Journal:  Neuroscience       Date:  2002       Impact factor: 3.590

8.  Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina.

Authors:  Minoru Tomita; Yasushi Adachi; Haruhiko Yamada; Kanji Takahashi; Katsuji Kiuchi; Haruki Oyaizu; Kazuya Ikebukuro; Hiroyuki Kaneda; Miyo Matsumura; Susumu Ikehara
Journal:  Stem Cells       Date:  2002       Impact factor: 6.277

9.  Neural differentiation of mouse embryonic stem cells in vitro and after transplantation into eyes of mutant mice with rapid retinal degeneration.

Authors:  Jason S Meyer; Martin L Katz; Joel A Maruniak; Mark D Kirk
Journal:  Brain Res       Date:  2004-07-16       Impact factor: 3.252

10.  Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells.

Authors:  Carla B Mellough; Qi Cui; Kirsty L Spalding; Natalie A Symons; Margaret A Pollett; Evan Y Snyder; Jeffrey D Macklis; Alan R Harvey
Journal:  Exp Neurol       Date:  2004-03       Impact factor: 5.330

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  1 in total

1.  An epidemiological approach for the estimation of disease onset in Central Europe in central and peripheral monogenic retinal dystrophies.

Authors:  Elena Prokofyeva; Robert Wilke; Gunnar Lotz; Eric Troeger; Torsten Strasser; Eberhart Zrenner
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2009-03-11       Impact factor: 3.117

  1 in total

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