PURPOSE OF REVIEW: During folliculogenesis the primordial follicle undergoes several steps of maturation in order to develop into a preovulatory follicle. The exact role of estrogen during this process has not yet been fully assessed. RECENT FINDINGS: Estrogen appears to regulate cyclic gonadotropin release via its action on estrogen receptor alpha in the hypothalamus/hypophysis axis and to enhance folliculogenesis through its actions via estrogen receptor beta in the ovary. In addition, a role of estrogen during the very early stages of folliculogenesis is possible. However, it is likely that oocyte quality and developmental potential are not estrogen dependent. This might explain the lack of association between estrogen and in-vitro fertilization outcome in humans. SUMMARY: The advent of knockout mice models has enhanced our understanding of the role of estrogen during folliculogenesis. Existing data suggest that estrogen might be involved in the very early steps of this process, but its role in sustaining ovulation is mainly central.
PURPOSE OF REVIEW: During folliculogenesis the primordial follicle undergoes several steps of maturation in order to develop into a preovulatory follicle. The exact role of estrogen during this process has not yet been fully assessed. RECENT FINDINGS: Estrogen appears to regulate cyclic gonadotropin release via its action on estrogen receptor alpha in the hypothalamus/hypophysis axis and to enhance folliculogenesis through its actions via estrogen receptor beta in the ovary. In addition, a role of estrogen during the very early stages of folliculogenesis is possible. However, it is likely that oocyte quality and developmental potential are not estrogen dependent. This might explain the lack of association between estrogen and in-vitro fertilization outcome in humans. SUMMARY: The advent of knockout mice models has enhanced our understanding of the role of estrogen during folliculogenesis. Existing data suggest that estrogen might be involved in the very early steps of this process, but its role in sustaining ovulation is mainly central.
Authors: Raíssa de Oliveira Ferreira; Abraão Tiago Batista Guimarães; Thiago Lopes Rocha; Aline Sueli de Lima Rodrigues; Bruna de Oliveira Mendes; Carlos Mesak; Guilherme Malafaia Journal: Environ Sci Pollut Res Int Date: 2018-10-27 Impact factor: 4.223
Authors: João P A Amorim; Luiz G A Chuffa; Giovana R Teixeira; Leonardo O Mendes; Beatriz A Fioruci; Otávio A Martins; Wílson Mello; Janete A Anselmo-Franci; Patricia F F Pinheiro; Marcelo Martinez; Francisco E Martinez Journal: Reprod Biol Endocrinol Date: 2011-12-22 Impact factor: 5.211