| Literature DB >> 15869856 |
Landon R Greene1, Anthony C Blackburn, Jonathan M Miller.
Abstract
A rapid gravimetric method for determining drug candidate solubility in organic solvents has been developed. The scale, speed, precision, and accuracy of the method make it ideal for solubility screening of pharmaceutical compounds during early development. The method utilizes a thermogravimetric analyzer to automate drying and weighing. Results for model compounds compare favorably with literature values.Mesh：
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Year: 2005 PMID： 15869856 DOI： 10.1016/j.jpba.2005.03.022
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935