| Literature DB >> 15869811 |
Vicente Micol1, Nuria Caturla, Laura Pérez-Fons, Vicente Más, Luis Pérez, Amparo Estepa.
Abstract
A commercial plant extract derived from olive tree leaf (Olea europaea) (LExt) and its major compound, oleuropein (Ole), inhibited the in vitro infectivity of the viral haemorrhagic septicaemia virus (VHSV), a salmonid rhabdovirus. Incubation of virus with LExt or Ole before infection reduced the viral infectivity to 10 and 30%, respectively. Furthermore, LExt drastically decreased VHSV titers and viral protein accumulation (virucidal effect) in a dose dependent manner when added to cell monolayers 36 h post-infection. On the other hand, both the LExt and Ole were able to inhibit cell-to-cell membrane fusion induced by VHSV in uninfected cells, suggesting interactions with viral envelope. Therefore, we propose that O. europaea could be used as a potential source of promising natural antivirals, which have demonstrated to lack impact on health and environment. In addition, Ole could be used to design other related antiviral agents.Entities:
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Year: 2005 PMID： 15869811 DOI： 10.1016/j.antiviral.2005.02.005
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970