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Literature DB >> 15869725

Complications of androgen-deprivation therapy in men with prostate cancer.

Abstract

Androgen-deprivation therapy (ADT) is indicated for the treatment of metastatic prostate cancer and locally advanced disease. In addition to sexual side effects, long-term ADT results in several other changes, including hot flashes; gynecomastia; changes in body composition, metabolism, and the cardiovascular system; osteoporosis; anemia; psychiatric and cognitive problems; and fatigue and diminished quality of life. This review discusses these complications of ADT and treatments aimed at reducing them. It is important for clinicians to anticipate these effects and to initiate measures to prevent or minimize them in order to maintain quality of life in prostate cancer survivors.

Entities: Chemical

Mesh：

Substances：
Androgen Antagonists

Year: 2005 PMID： 15869725 DOI： 10.1007/s11934-005-0009-2

Source DB: PubMed Journal: Curr Urol Rep ISSN： 1527-2737 Impact factor: 2.862

59 in total

Review 1. Gynecomastia in patients with prostate cancer: a review of treatment options.

Authors: D G McLeod; P Iversen
Journal: Urology Date: 2000-11-01 Impact factor: 2.649

2. Effects of exercise on physiological and psychological variables in cancer survivors.

Authors: Timothy R Burnham; Anthony Wilcox
Journal: Med Sci Sports Exerc Date: 2002-12 Impact factor: 5.411

3. Sex steroids modify working memory.

Authors: J S Janowsky; B Chavez; E Orwoll
Journal: J Cogn Neurosci Date: 2000-05 Impact factor: 3.225

4. Transdermal estrogen in the treatment of hot flushes in men with prostate cancer.

Authors: G S Gerber; G P Zagaja; P S Ray; D B Rukstalis
Journal: Urology Date: 2000-01 Impact factor: 2.649

5. The effect of micronized estradiol on bone turnover and calciotropic hormones in older men receiving hormonal suppression therapy for prostate cancer.

Authors: Pamela Taxel; Pamela M Fall; Peter C Albertsen; Robert D Dowsett; Margaret Trahiotis; Jill Zimmerman; Christine Ohannessian; Lawrence G Raisz
Journal: J Clin Endocrinol Metab Date: 2002-11 Impact factor: 5.958

6. Effects of gonadectomy on immunoreactivity for choline acetyltransferase in the cortex, hippocampus, and basal forebrain of adult male rats.

Authors: N Nakamura; H Fujita; M Kawata
Journal: Neuroscience Date: 2002 Impact factor: 3.590

Review 7. Hematologic effects of androgens revisited: an alternative therapy in various hematologic conditions.

Authors: E C Besa
Journal: Semin Hematol Date: 1994-04 Impact factor: 3.851

8. Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer.

Authors: M R Smith; F J McGovern; A L Zietman; M A Fallon; D L Hayden; D A Schoenfeld; P W Kantoff; J S Finkelstein
Journal: N Engl J Med Date: 2001-09-27 Impact factor: 91.245

9. Progressive osteoporosis during androgen deprivation therapy for prostate cancer.

Authors: H W Daniell; S R Dunn; D W Ferguson; G Lomas; Z Niazi; P T Stratte
Journal: J Urol Date: 2000-01 Impact factor: 7.450

10. Changes in body composition during androgen deprivation therapy for prostate cancer.

Authors: Matthew R Smith; Joel S Finkelstein; Francis J McGovern; Anthony L Zietman; Mary Anne Fallon; David A Schoenfeld; Philip W Kantoff
Journal: J Clin Endocrinol Metab Date: 2002-02 Impact factor: 5.958

7 in total

1. Effects of surgical and chemical castration on spatial learning ability in relation to cell proliferation and apoptosis in hippocampus.

Authors: Mal-Soon Shin; Kyung Jin Chung; Il-Gyu Ko; Sang-Hoon Kim; Jun-Jang Jin; Sung-Eun Kim; Jae-Min Lee; Eun-Sang Ji; Tae-Woon Kim; Han-Sam Cho; Chang Hee Kim; Young-Sam Cho; Chang-Ju Kim; Khae-Hawn Kim
Journal: Int Urol Nephrol Date: 2016-01-18 Impact factor: 2.370

Complications of androgen-deprivation therapy in men with prostate cancer.

Review 1. Gynecomastia in patients with prostate cancer: a review of treatment options.

2. Effects of exercise on physiological and psychological variables in cancer survivors.

3. Sex steroids modify working memory.

4. Transdermal estrogen in the treatment of hot flushes in men with prostate cancer.

5. The effect of micronized estradiol on bone turnover and calciotropic hormones in older men receiving hormonal suppression therapy for prostate cancer.

6. Effects of gonadectomy on immunoreactivity for choline acetyltransferase in the cortex, hippocampus, and basal forebrain of adult male rats.

Review 7. Hematologic effects of androgens revisited: an alternative therapy in various hematologic conditions.

8. Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer.

9. Progressive osteoporosis during androgen deprivation therapy for prostate cancer.

10. Changes in body composition during androgen deprivation therapy for prostate cancer.

1. Effects of surgical and chemical castration on spatial learning ability in relation to cell proliferation and apoptosis in hippocampus.

2. Targeting MMP-9, uPAR, and cathepsin B inhibits invasion, migration and activates apoptosis in prostate cancer cells.

Review 3. Quality of life issues in men undergoing androgen deprivation therapy: a review.

4. Prospective study of depression and fatigue in men with advanced prostate cancer receiving hormone therapy.

5. Do hormone treatments for prostate cancer cause anxiety and depression?

6. Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer.

7. A pilot study of exercise in men with prostate cancer receiving androgen deprivation therapy.