Literature DB >> 15869686

QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone.

Stavros P Kounas1, Konstantinos P Letsas, Antonios Sideris, Michalis Efraimidis, Fotios Kardaras.   

Abstract

This report documents the occurrence of torsades de pointes (TdP) caused by marked QT interval prolongation in the case of a 71-year-old woman receiving both metronidazole and amiodarone for the treatment of pseudomembranous colitis and paroxysmal atrial fibrillation. The case highlights a previously unknown drug interaction. The role of inhibition of cytochrome P-450 CYP3A4 is discussed.

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Year:  2005        PMID： 15869686     DOI： 10.1111/j.1540-8159.2005.09348.x

Source DB:  PubMed          Journal:  Pacing Clin Electrophysiol        ISSN： 0147-8389            Impact factor:   1.976


  5 in total

1.  Prevalence and Risk Factors Associated with Use of QT-Prolonging Drugs in Hospitalized Older People.

Authors:  C Franchi; I Ardoino; R Rossio; A Nobili; E M Biganzoli; A Marengoni; M Marcucci; L Pasina; M Tettamanti; S Corrao; P M Mannucci
Journal:  Drugs Aging       Date:  2016-01       Impact factor: 3.923

2.  Effect of metronidazole on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy male volunteers.

Authors:  Kyoung-Ah Kim; Ji-Young Park
Journal:  Eur J Clin Pharmacol       Date:  2010-03-20       Impact factor: 2.953

3.  A Rare Case of Metronidazole Overdose Causing Ventricular Fibrillation.

Authors:  Mohamed Abdelgadir M Elgassim; Amin Saied Sanosi Saied; Moayad A Mustafa; Amro Abdelrahman; Ibtesam AlJaufi; Waleed Salem
Journal:  Cureus       Date:  2022-05-04

Review 4.  Exposure to antibacterial agents with QT liability in 14 European countries: trends over an 8-year period.

Authors:  Emanuel Raschi; Elisabetta Poluzzi; Chiara Zuliani; Arno Muller; Herman Goossens; Fabrizio De Ponti
Journal:  Br J Clin Pharmacol       Date:  2008-11-17       Impact factor: 4.335

5.  Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

Authors:  Adam P Hill; Matthew D Perry; Najah Abi-Gerges; Jean-Philippe Couderc; Bernard Fermini; Jules C Hancox; Bjorn C Knollmann; Gary R Mirams; Jon Skinner; Wojciech Zareba; Jamie I Vandenberg
Journal:  J Physiol       Date:  2016-06-09       Impact factor: 5.182
  5 in total

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