Literature DB >> 15867015

What caused the epidemic of Pneumocystis pneumonia in European premature infants in the mid-20th century?

Armond S Goldman1, Lynn R Goldman, Daniel A Goldman.   

Abstract

An epidemic of interstitial pneumonia principally involving premature infants occurred in Germany and nearby European countries between the 1920s and 1960s. Fatalities were due to Pneumocystis. Because the principal defenses against Pneumocystis are T cells, an acquired T-cell deficiency was postulated. A number of potential causes including malnutrition were considered. All were implausible except for a retrovirus that was benign in adults but virulent in premature infants. Furthermore, we suspect that the virus was imported into Germany from former German African colonies. Premature infants were vulnerable because of the developmental status of their T cells. Given the practices in that part of Europe at that time, the virus was most likely transmitted by contaminated blood transfusions and subsequent contamination of reusable needles and syringes used in injections. Although the epidemic ended 4 decades ago, a search for the postulated retrovirus can be conducted if tissues from affected infants are available.

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Year:  2005        PMID: 15867015     DOI: 10.1542/peds.2004-2157

Source DB:  PubMed          Journal:  Pediatrics        ISSN: 0031-4005            Impact factor:   7.124


  6 in total

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Authors:  L Beth Gadkowski; Jason E Stout
Journal:  Clin Microbiol Rev       Date:  2008-04       Impact factor: 26.132

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Journal:  Infect Immun       Date:  2018-01-22       Impact factor: 3.441

Review 3.  A Molecular Window into the Biology and Epidemiology of Pneumocystis spp.

Authors:  Liang Ma; Ousmane H Cissé; Joseph A Kovacs
Journal:  Clin Microbiol Rev       Date:  2018-06-13       Impact factor: 26.132

4.  Complexity of the MSG gene family of Pneumocystis carinii.

Authors:  Scott P Keely; James R Stringer
Journal:  BMC Genomics       Date:  2009-08-07       Impact factor: 3.969

5.  Diagnosis of Pneumocystis jirovecii Pneumonia in Pediatric Patients in Serbia, Greece, and Romania. Current Status and Challenges for Collaboration.

Authors:  Valentina Arsić Arsenijevic; Timoleon-Achilleas Vyzantiadis; Mihai Mares; Suzana Otasevic; Athanasios Tragiannidis; Dragana Janic
Journal:  J Fungi (Basel)       Date:  2020-04-17

6.  Pneumocystis jirovecii pneumonia as an initial manifestation of hyper-IgM syndrome in an infant: A case report.

Authors:  Danbi Kim; Ju Ae Shin; Seung Beom Han; Nack-Gyun Chung; Dae Chul Jeong
Journal:  Medicine (Baltimore)       Date:  2019-02       Impact factor: 1.817

  6 in total

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