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Literature DB >> 15866946

The Salmonella translocated effector SopA is targeted to the mitochondria of infected cells.

Abigail N Layton¹, Philip J Brown, Edouard E Galyov.

Abstract

This study investigates the Salmonella effector protein SopA. We show that in Salmonella enterica serovar Dublin-infected cells, SopA(1-347) fused to two carboxy-terminal hemagglutinin tags partially colocalized with mitochondria. Transfection of eukaryotic cells with a panel of constructs encoding truncated versions of SopA identified that amino acids 100 to 347 were sufficient to target SopA to the mitochondria.

Entities: Chemical

Mesh：

Substances：

Year: 2005 PMID： 15866946 PMCID： PMC1112013 DOI： 10.1128/JB.187.10.3565-3571.2005

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

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