Literature DB >> 15866943

Severity of the streptomycin resistance and streptomycin dependence phenotypes of ribosomal protein S12 of Thermus thermophilus depends on the identity of highly conserved amino acid residues.

Jennifer F Carr1, Steven T Gregory, Albert E Dahlberg.   

Abstract

The structural basis for the streptomycin dependence phenotype of ribosomal protein S12 mutants is poorly understood. Here we describe the application of site-directed mutagenesis and gene replacement of Thermus thermophilus rpsL to assess the importance of side chain identity and tertiary interactions as phenotypic determinants of drug-dependent mutants.

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Year:  2005        PMID： 15866943      PMCID： PMC1111998          DOI： 10.1128/JB.187.10.3548-3550.2005

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  12 in total

1.  Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA.

Authors:  Ditlev E Brodersen; William M Clemons; Andrew P Carter; Brian T Wimberly; V Ramakrishnan
Journal:  J Mol Biol       Date:  2002-02-22       Impact factor: 5.469

2.  Structure of the 30S ribosomal subunit.

Authors:  B T Wimberly; D E Brodersen; W M Clemons; R J Morgan-Warren; A P Carter; C Vonrhein; T Hartsch; V Ramakrishnan
Journal:  Nature       Date:  2000-09-21       Impact factor: 49.962

3.  Selection of tRNA by the ribosome requires a transition from an open to a closed form.

Authors:  James M Ogle; Frank V Murphy; Michael J Tarry; V Ramakrishnan
Journal:  Cell       Date:  2002-11-27       Impact factor: 41.582

4.  Isolation of Halotolerant Thermus spp. from Submarine Hot Springs in Iceland.

Authors:  J K Kristjansson; G O Hreggvidsson; G A Alfredsson
Journal:  Appl Environ Microbiol       Date:  1986-12       Impact factor: 4.792

5.  Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium.

Authors:  J Björkman; P Samuelsson; D I Andersson; D Hughes
Journal:  Mol Microbiol       Date:  1999-01       Impact factor: 3.501

6.  Ribosomal protein S12 as a site for streptomycin resistance in Nicotiana chloroplasts.

Authors:  S Galili; H Fromm; D Aviv; M Edelman; E Galun
Journal:  Mol Gen Genet       Date:  1989-08

7.  Double, independent mutational events in the rpsL gene of Escherichia coli: an example of hypermutability?

Authors:  A R Timms; B A Bridges
Journal:  Mol Microbiol       Date:  1993-07       Impact factor: 3.501

8.  Streptomycin-resistant and streptomycin-dependent mutants of the extreme thermophile Thermus thermophilus.

Authors:  S T Gregory; J H Cate; A E Dahlberg
Journal:  J Mol Biol       Date:  2001-06-01       Impact factor: 5.469

9.  Thiostrepton-resistant mutants of Thermus thermophilus.

Authors:  Dale M Cameron; Jill Thompson; Steven T Gregory; Paul E March; Albert E Dahlberg
Journal:  Nucleic Acids Res       Date:  2004-06-15       Impact factor: 16.971

10.  Genetic transformation of the extreme thermophile Thermus thermophilus and of other Thermus spp.

Authors:  Y Koyama; T Hoshino; N Tomizuka; K Furukawa
Journal:  J Bacteriol       Date:  1986-04       Impact factor: 3.490
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  13 in total

1.  Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome.

Authors:  Divya Sharma; Anthony R Cukras; Elizabeth J Rogers; Daniel R Southworth; Rachel Green
Journal:  J Mol Biol       Date:  2007-10-06       Impact factor: 5.469

2.  Effects of streptomycin resistance mutations on posttranslational modification of ribosomal protein S12.

Authors:  Jennifer F Carr; Daisy-Malloy Hamburg; Steven T Gregory; Patrick A Limbach; Albert E Dahlberg
Journal:  J Bacteriol       Date:  2006-03       Impact factor: 3.490

3.  A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.

Authors:  Guojun Wang; Takashi Inaoka; Susumu Okamoto; Kozo Ochi
Journal:  Antimicrob Agents Chemother       Date:  2008-12-22       Impact factor: 5.191

4.  A signal relay between ribosomal protein S12 and elongation factor EF-Tu during decoding of mRNA.

Authors:  Steven T Gregory; Jennifer F Carr; Albert E Dahlberg
Journal:  RNA       Date:  2008-12-17       Impact factor: 4.942

5.  Mutations in conserved helix 69 of 23S rRNA of Thermus thermophilus that affect capreomycin resistance but not posttranscriptional modifications.

Authors:  Tanakarn Monshupanee; Steven T Gregory; Stephen Douthwaite; Wipa Chungjatupornchai; Albert E Dahlberg
Journal:  J Bacteriol       Date:  2008-09-19       Impact factor: 3.490

6.  Mutational analysis of 16S and 23S rRNA genes of Thermus thermophilus.

Authors:  Steven T Gregory; Jennifer F Carr; Daniel Rodriguez-Correa; Albert E Dahlberg
Journal:  J Bacteriol       Date:  2005-07       Impact factor: 3.490

7.  Phenotypic Suppression of Streptomycin Resistance by Mutations in Multiple Components of the Translation Apparatus.

Authors:  Jennifer F Carr; Hannah J Lee; Joshua B Jaspers; Albert E Dahlberg; Gerwald Jogl; Steven T Gregory
Journal:  J Bacteriol       Date:  2015-07-06       Impact factor: 3.490

8.  A proteomic and transcriptomic approach reveals new insight into beta-methylthiolation of Escherichia coli ribosomal protein S12.

Authors:  Michael Brad Strader; Nina Costantino; Christopher A Elkins; Cai Yun Chen; Isha Patel; Anthony J Makusky; John S Choy; Donald L Court; Sanford P Markey; Jeffrey A Kowalak
Journal:  Mol Cell Proteomics       Date:  2010-12-17       Impact factor: 5.911

9.  Genetic and structural analysis of base substitutions in the central pseudoknot of Thermus thermophilus 16S ribosomal RNA.

Authors:  Steven T Gregory; Albert E Dahlberg
Journal:  RNA       Date:  2009-02       Impact factor: 4.942

10.  Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG.

Authors:  Steven T Gregory; Hasan Demirci; Riccardo Belardinelli; Tanakarn Monshupanee; Claudio Gualerzi; Albert E Dahlberg; Gerwald Jogl
Journal:  RNA       Date:  2009-07-21       Impact factor: 4.942
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