Literature DB >> 15866612

GSTT1 and GSTM1 polymorphisms are associated with improvement in seminal findings after varicocelectomy.

Kazutoshi Okubo1, Kanji Nagahama, Toshiyuki Kamoto, Hiroshi Okuno, Osamu Ogawa, Hiroyuki Nishiyama.   

Abstract

To identify the best candidates for varicocelectomy, we evaluated the genetic polymorphism in glutathione S-transferase (GST) T1 and M1 in 38 infertile men with high-grade varicocele testis who underwent varicocelectomy. The response rate to varicocelectomy is significantly higher in patients with the GSTT1-wt genotype than the GSTT1-null genotype, and the response rate became higher in combination with the GSTM1 genotype.

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Year:  2005        PMID： 15866612     DOI： 10.1016/j.fertnstert.2004.11.057

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  4 in total

1.  Preliminary examination of polymorphisms of GSTM1, GSTT1, and GSTZ1 in relation to semen quality.

Authors:  Andrew F Olshan; Thomas J Luben; Nancy M Hanley; Sally D Perreault; Ronna L Chan; Amy H Herring; Patricia V Basta; David M DeMarini
Journal:  Mutat Res       Date:  2010-03-07       Impact factor: 2.433

2.  Genetic polymorphisms in glutathione S-transferase T1 affect the surgical outcome of varicocelectomies in infertile patients.

Authors:  Kentaro Ichioka; Kanji Nagahama; Kazutoshi Okubo; Takeshi Soda; Osamu Ogawa; Hiroyuki Nishiyama
Journal:  Asian J Androl       Date:  2009-01-19       Impact factor: 3.285

3.  Varicocele-induced infertility: Newer insights into its pathophysiology.

Authors:  Michael L Eisenberg; Larry I Lipshultz
Journal:  Indian J Urol       Date:  2011-01

4.  Glutathione S-transferase T1: a potential marker for the selection of varicocelectomy in infertile male patients with varicocele.

Authors:  Qi-Fei Wu; Kai-Fa Tang; Jian-Hua Sun; Jun-Ping Xing
Journal:  Asian J Androl       Date:  2015 Sep-Oct       Impact factor: 3.285
  4 in total

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