| Literature DB >> 15866362 |
Peruvamba N Jayakumar1, Ganesan Venkatasubramanian, Bangalore N Gangadhar, Nimmagadda Janakiramaiah, Matcheri S Keshavan.
Abstract
This study examined gray matter (GM) volume abnormalities in first-episode, antipsychotic-naïve Indian schizophrenia patients. Magnetic resonance images of 18 schizophrenia patients and 18 matched healthy comparison subjects were analyzed by optimized voxel-based morphometry. Schizophrenia patients had significantly smaller global GM and greater global CSF volumes and smaller regional GM volume in superior frontal, inferior frontal, cingulate, post-central, superior temporal and parahippocampal gyri, inferior parietal lobule, insula, caudate nuclei, thalamus and cerebellum. Findings suggest limbic, heteromodal cortical, striatal, thalamic and cerebellar abnormalities in schizophrenia.Entities:
Mesh：
Year: 2005 PMID： 15866362 DOI： 10.1016/j.pnpbp.2005.01.020
Source DB: PubMed Journal: Prog Neuropsychopharmacol Biol Psychiatry ISSN： 0278-5846 Impact factor: 5.067