| Literature DB >> 15866236 |
Nicholas van Panhuys1, Rachel Perret, Melanie Prout, Franca Ronchese, Graham Le Gros.
Abstract
It is often argued that T cell-mediated immunity to secondary infection is dependent on the 'accelerated' responses of memory T cells in lymph nodes. However, new evidence points to a crucial role for effector memory T cells, which are resident in peripheral tissues, in immune protection. These T cells, which reside in peripheral tissues, are not necessarily bound by an anatomical structure and can be present at many sites. Collectively, they represent a third functional tissue of the immune system, uniquely specialized to mediate protective immunity. We propose that the paradigm 'effector lymphoid tissue' needs to be articulated and developed as a focus of new research to describe and understand the unique role this tissue has in protective immunity.Entities:
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Year: 2005 PMID： 15866236 DOI： 10.1016/j.it.2005.03.005
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687