OBJECTIVE: Several predisposing factors to insomnia have been hypothesized, including a familial component; however, few studies have focused on this topic. The aim of this study is to evaluate the prevalence of insomnia among first-degree relatives of chronic insomniacs and to compare the symptoms between sporadic and familial insomnia. METHODS: Two hundred fifty-six consecutive chronic insomniacs completed a clinical interview, psychometric questionnaires, a questionnaire on the family history of insomnia and, when indicated, a polysomnography. A control group was performed to estimate a base-rate incidence of insomnia in their families. RESULTS: Patients with primary (n=77) and psychiatric (n=104) insomnia were definitely included. Of those with primary insomnia, 72.7% reported familial insomnia compared with 24.1% in the noninsomnia control group. Among the psychiatric insomniacs, 43.3% reported familial insomnia. The mother was the relative most frequently affected. Comparisons between the family prevalence rates of insomnia assessed by the probands and by first-degree relatives show high concordance. A tendency to a younger age at onset was observed in familial and primary insomnia. CONCLUSION: This study reports a significant increase of familial aggregation of insomnia, warranting further genetic studies in primary insomnia with early age at onset.
OBJECTIVE: Several predisposing factors to insomnia have been hypothesized, including a familial component; however, few studies have focused on this topic. The aim of this study is to evaluate the prevalence of insomnia among first-degree relatives of chronic insomniacs and to compare the symptoms between sporadic and familial insomnia. METHODS: Two hundred fifty-six consecutive chronic insomniacs completed a clinical interview, psychometric questionnaires, a questionnaire on the family history of insomnia and, when indicated, a polysomnography. A control group was performed to estimate a base-rate incidence of insomnia in their families. RESULTS:Patients with primary (n=77) and psychiatric (n=104) insomnia were definitely included. Of those with primary insomnia, 72.7% reported familial insomnia compared with 24.1% in the noninsomnia control group. Among the psychiatric insomniacs, 43.3% reported familial insomnia. The mother was the relative most frequently affected. Comparisons between the family prevalence rates of insomnia assessed by the probands and by first-degree relatives show high concordance. A tendency to a younger age at onset was observed in familial and primary insomnia. CONCLUSION: This study reports a significant increase of familial aggregation of insomnia, warranting further genetic studies in primary insomnia with early age at onset.
Authors: Mikhil N Bamne; Hader Mansour; Timothy H Monk; Daniel J Buysse; Vishwajit L Nimgaonkar Journal: Sleep Med Rev Date: 2010-03-17 Impact factor: 11.609
Authors: Michael Deuschle; Michael Schredl; Claudia Schilling; Stefan Wüst; Josef Frank; Stephanie H Witt; Marcella Rietschel; Magdalena Buckert; Andreas Meyer-Lindenberg; Thomas G Schulze Journal: Sleep Date: 2010-03 Impact factor: 5.849
Authors: Beverly H Brummett; Andrew D Krystal; Allison Ashley-Koch; Cynthia M Kuhn; Stephan Züchner; Ilene C Siegler; John C Barefoot; Edna L Ballard; Lisa P Gwyther; Redford B Williams Journal: Psychosom Med Date: 2007-08-31 Impact factor: 4.312
Authors: Olivia J Veatch; Julie S Pendergast; Melissa J Allen; Roberta M Leu; Carl Hirschie Johnson; Sarah H Elsea; Beth A Malow Journal: J Autism Dev Disord Date: 2015-01