Literature DB >> 15864722

The antioxidant effect of beta-Glucan on oxidative stress status in experimental spinal cord injury in rats.

Hakan Kayali1, M Fatih Ozdag, Serdar Kahraman, Ahmet Aydin, Engin Gonul, Ahmet Sayal, Zeki Odabasi, Erdener Timurkaynak.   

Abstract

This study was performed to investigate the antioxidant effect of beta-Glucan in experimental spinal cord injury (SCI). Injury was produced using weight-drop technique in rats. beta-Glucan was given by intraperitoneal injection following trauma. The rats were sacrificed at the sixth day of injury. Oxidative stress status was assessed by measuring the spinal cord tissue content of Malonyldialdehyde (MDA), Superoxide Dismutase (SOD) and Gluthatione Peroxidase (GSH-Px) activities. No effect of beta-Glucan on SOD and MDA activities was found but, GSH-Px levels were found to decrease to the baseline (preinjury) levels when it was compared to untreated group (U=0.000; p=0.002). According to our results, beta-Glucan works like a scavenger and has an antioxidant effect on lipid peroxidation in spinal cord injury.

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Year:  2005        PMID： 15864722     DOI： 10.1007/s10143-005-0389-2

Source DB:  PubMed          Journal:  Neurosurg Rev        ISSN： 0344-5607            Impact factor:   3.042


  61 in total

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  8 in total

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7.  The properties and formation mechanism of oat β-glucan mixed gels with different molecular weight composition induced by high-pressure processing.

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8.  Effects of Dietary Yeast β-Glucan Supplementation on Meat Quality, Antioxidant Capacity and Gut Microbiota of Finishing Pigs.

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  8 in total

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