PURPOSE: To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma. METHODS: We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase. RESULTS: The frequency of the GSTM1 null genotype individuals among the glaucoma patients was significanlty higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95% CI: 1.10-2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different. CONCLUSION: The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic-metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma.
PURPOSE: To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma. METHODS: We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase. RESULTS: The frequency of the GSTM1 null genotype individuals among the glaucomapatients was significanlty higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95% CI: 1.10-2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different. CONCLUSION: The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic-metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma.
Authors: M Deakin; J Elder; C Hendrickse; D Peckham; D Baldwin; C Pantin; N Wild; P Leopard; D A Bell; P Jones; H Duncan; K Brannigan; J Alldersea; A A Fryer; R C Strange Journal: Carcinogenesis Date: 1996-04 Impact factor: 4.944
Authors: H Duncan; C Swan; J Green; P Jones; K Brannigan; J Alldersea; A A Fryer; R C Strange Journal: Clin Chim Acta Date: 1995-08-31 Impact factor: 3.786
Authors: E M Stone; J H Fingert; W L Alward; T D Nguyen; J R Polansky; S L Sunden; D Nishimura; A F Clark; A Nystuen; B E Nichols; D A Mackey; R Ritch; J W Kalenak; E R Craven; V C Sheffield Journal: Science Date: 1997-01-31 Impact factor: 47.728
Authors: S Pemble; K R Schroeder; S R Spencer; D J Meyer; E Hallier; H M Bolt; B Ketterer; J B Taylor Journal: Biochem J Date: 1994-05-15 Impact factor: 3.857
Authors: J E McWilliams; B J Sanderson; E L Harris; K E Richert-Boe; W D Henner Journal: Cancer Epidemiol Biomarkers Prev Date: 1995-09 Impact factor: 4.254
Authors: Miroslav Stamenkovic; Vesna Lukic; Sonja Suvakov; Tatjana Simic; Ivan Sencanic; Marija Pljesa-Ercegovac; Vesna Jaksic; Sinisa Babovic; Marija Matic; Aleksandra Radosavljevic; Ana Savic-Radojevic; Tatjana Djukic Journal: Int J Ophthalmol Date: 2018-09-18 Impact factor: 1.779
Authors: Auta Viviane Rocha; Teddy Talbot; Thiago Magalhães da Silva; Maria Clarinda Almeida; Carlos Alberto Menezes; Giuliano Di Pietro; Fabrício Rios-Santos Journal: Mol Vis Date: 2011-06-23 Impact factor: 2.367
Authors: Thomas Boillot; Serge G Rosolen; Thomas Dulaurent; Frédéric Goulle; Philippe Thomas; Pierre-François Isard; Thierry Azoulay; Stéphanie Lafarge-Beurlet; Mike Woods; Sylvie Lavillegrand; Ivana Ivkovic; Nathalie Neveux; José-Alain Sahel; Serge Picaud; Nicolas Froger Journal: PLoS One Date: 2014-11-07 Impact factor: 3.240
Authors: Haixi Miao; Lin Chen; Sean M Riordan; Wenjun Li; Santiago Juarez; Andrea M Crabb; Thomas J Lukas; Pan Du; Simon M Lin; Alexandria Wise; Olga A Agapova; Ping Yang; Charles C Gu; M Rosario Hernandez Journal: PLoS One Date: 2008-08-06 Impact factor: 3.240