Intramedullary and extramedullary fat globules on magnetic resonance imaging as a diagnostic sign for osteomyelitis.

We retrospectively studied the frequency of persistent foci of fat signal on magnetic resonance (MR) imaging in osteomyelitis to assess its frequency, cause and diagnostic value. The radiographs and MR scans of 100 patients with a final diagnosis of osteomyelitis referred to a specialist orthopaedic oncology service with the presumptive diagnosis of a bone tumour were reviewed. The MR signal and morphological characteristics were recorded with particular attention to the presence of persistent fat signal within the infected area, which was classified as diffuse or focal. Seventeen cases were classified on radiographic grounds as acute, 63 as subacute and 20 as chronic osteomyelitis. In the acute group 12 (70%) showed replacement of the marrow with fluid containing residual fatty signal, diffuse in seven and focal in five cases. Two cases showed predominantly fatty marrow with very early marrow oedema and three cases (18%) showed replacement of marrow fat with fluid and no residual fatty foci. None of the subacute group showed foci of fatty signal and two cases of inactive sclerosing osyeomyelitis in the chronic group showed restoration of normal marrow. Persistent fatty signal within the bone as well as soft tissues on MR imaging is a frequent finding in acute osteomyelitis. Radiological-pathological correlation suggests that the increasing intramedullary pressure leads to septic necrosis with death of the lipocytes and release of free fatty globules. This characteristic, but not pathognomonic, MR finding supports the diagnosis of osteomyelitis and may help to exclude the presence of a tumour.