Literature DB >> 15864266

Cancer drug discovery through collaboration.

Christoph Lengauer1, Luis A Diaz, Saurabh Saha.   

Abstract

It has been two decades since cancer was first described as a genetic disease and researchers offered the promise of early diagnosis and targeted therapies. Today, most cancer patients still await life-saving treatments. Genomics and other '-omics' technologies have revealed a complexity among cancers that makes almost any tumour genetically unique; as a consequence, effective targeted therapies might be suitable only for small subgroups of patients. We suggest that by merging and organizing their core competencies, academia, biotechnology companies and the pharmaceutical industry can address existing bottlenecks in anticancer drug discovery and development.

Entities:  

Mesh:

Substances:

Year:  2005        PMID: 15864266     DOI: 10.1038/nrd1722

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


  6 in total

1.  The role of funding and policies on innovation in cancer drug development.

Authors:  P Kanavos; R Sullivan; G Lewison; W Schurer; S Eckhouse; Z Vlachopioti
Journal:  Ecancermedicalscience       Date:  2010-02-03

Review 2.  Next-generation clinical trials: Novel strategies to address the challenge of tumor molecular heterogeneity.

Authors:  Daniel V T Catenacci
Journal:  Mol Oncol       Date:  2014-10-18       Impact factor: 6.603

Review 3.  Advanced Cellular Models for Preclinical Drug Testing: From 2D Cultures to Organ-on-a-Chip Technology.

Authors:  Valentina Foglizzo; Emiliano Cocco; Serena Marchiò
Journal:  Cancers (Basel)       Date:  2022-07-28       Impact factor: 6.575

4.  Local and global modes of drug action in biochemical networks.

Authors:  Jean-Marc Schwartz; Jose C Nacher
Journal:  BMC Chem Biol       Date:  2009-04-07

5.  Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53-HDM2 Protein-Protein Interaction.

Authors:  Peter M Fischer
Journal:  Int J Pept Res Ther       Date:  2006-03-15       Impact factor: 1.931

Review 6.  Cytotoxic and antitumor peptides as novel chemotherapeutics.

Authors:  Xin Luan; Ye Wu; Yi-Wen Shen; Hong Zhang; Yu-Dong Zhou; Hong-Zhuan Chen; Dale G Nagle; Wei-Dong Zhang
Journal:  Nat Prod Rep       Date:  2020-08-10       Impact factor: 15.111

  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.