Literature DB >> 15863929

Synthesis of poison-frog alkaloids 237D, 207A, and two congeners of 235B' for evaluation to inhibitory effect of nicotinic acetylcholine receptors.

Naoki Toyooka1, Masashi Kawasaki, Hideo Nemoto.   

Abstract

Enantioselective synthesis of the poison-frog alkaloids 237D, 207A, and two congeners of 235B' has been achieved. The absolute stereochemistry of 237D was determined to be 5S, 8S, 9R by the present synthesis.

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Year:  2005        PMID： 15863929     DOI： 10.1248/cpb.53.555

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  1 in total

1.  Indolizidine (-)-235B' and related structural analogs: discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release.

Authors:  Marharyta Pivavarchyk; Andrew M Smith; Zhenfa Zhang; Dejun Zhou; Xu Wang; Naoki Toyooka; Hiroshi Tsuneki; Toshiyasu Sasaoka; J Michael McIntosh; Peter A Crooks; Linda P Dwoskin
Journal:  Eur J Pharmacol       Date:  2011-03-01       Impact factor: 4.432
  1 in total

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