| Literature DB >> 15863902 |
Fernanda Emendörfer1, Fabiane Emendörfer, Fernanda Bellato, Vânia Floriani Noldin, Valdir Cechinel-Filho, Rosendo Augusto Yunes, Franco Delle Monache, Alcíbia Maia Cardozo.
Abstract
This study describes the antispasmodic activity of some fractions and cynaropicrin, a sesquiterpene lactone from Cynara scolymus, cultivated in Brazil, against guinea-pig ileum contracted by acetylcholine. The dichloromethane fraction showed the most promising biological effects, with an IC(50) of 0.93 (0.49-1.77) mg/ml. Its main active component, the sesquiterpene lactone cynaropicrin, exhibited potent activity, with IC(50) of 0.065 (0.049-0.086) mg/ml, being about 14-fold more active than dichloromethane fraction and having similar potency to that of papaverine, a well-known antispasmodic agent. The results confirm the popular use of artichoke for the treatment of gastrointestinal disturbances, and encourage new studies on this compound, in order to obtain new antispasmodic agents.Entities:
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Year: 2005 PMID： 15863902 DOI： 10.1248/bpb.28.902
Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233