OBJECTIVE: The authors evaluated the association of three functional promoter polymorphisms of the ADH4 gene with alcohol dependence. METHOD: DNA from 92 alcohol-dependent patients and 92 healthy comparison subjects was genotyped for all three polymorphisms. RESULTS: Variants at the -75 base-pair (bp) (C allele) and -159 bp (A allele) positions were associated with alcohol dependence. Individuals with haplotypes carrying both risk alleles showed an odds ratio of 2.9. CONCLUSIONS: These preliminary results suggest that ADH4 may play a role in the etiology of alcohol dependence. The association requires further study and replication but is functionally plausible and has a large effect size.
OBJECTIVE: The authors evaluated the association of three functional promoter polymorphisms of the ADH4 gene with alcohol dependence. METHOD: DNA from 92 alcohol-dependent patients and 92 healthy comparison subjects was genotyped for all three polymorphisms. RESULTS: Variants at the -75 base-pair (bp) (C allele) and -159 bp (A allele) positions were associated with alcohol dependence. Individuals with haplotypes carrying both risk alleles showed an odds ratio of 2.9. CONCLUSIONS: These preliminary results suggest that ADH4 may play a role in the etiology of alcohol dependence. The association requires further study and replication but is functionally plausible and has a large effect size.
Authors: Ian R Gizer; Howard J Edenberg; David A Gilder; Kirk C Wilhelmsen; Cindy L Ehlers Journal: Alcohol Clin Exp Res Date: 2011-06-02 Impact factor: 3.455
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Authors: Stuart Macgregor; Penelope A Lind; Kathleen K Bucholz; Narelle K Hansell; Pamela A F Madden; Melinda M Richter; Grant W Montgomery; Nicholas G Martin; Andrew C Heath; John B Whitfield Journal: Hum Mol Genet Date: 2008-11-07 Impact factor: 6.150
Authors: Leah Wetherill; Marc A Schuckit; Victor Hesselbrock; Xiaoling Xuei; Tiebing Liang; Danielle M Dick; John Kramer; John I Nurnberger; Jay A Tischfield; Bernice Porjesz; Howard J Edenberg; Tatiana Foroud Journal: Alcohol Clin Exp Res Date: 2008-09-25 Impact factor: 3.455
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Authors: Lucinda G Carr; Mark W Kimpel; Tiebing Liang; Jeanette N McClintick; Kevin McCall; Melissa Morse; Howard J Edenberg Journal: Alcohol Clin Exp Res Date: 2007-04-19 Impact factor: 3.455