Literature DB >> 15863339

Identification of chemokine receptor CCR4 antagonist.

Ashok V Purandare1, Aiming Gao, Honghe Wan, John Somerville, Christine Burke, Carrie Seachord, Wayne Vaccaro, John Wityak, Michael A Poss.   

Abstract

The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.

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Year:  2005        PMID： 15863339     DOI： 10.1016/j.bmcl.2005.02.084

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  2-cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action.

Authors:  Demetrio Raffa; Benedetta Maggio; Maria Valeria Raimondi; Maria Grazia Cusimano; Giandomenico Amico; Anna Carollo; Pier Giulio Conaldi; Ruoli Bai; Ernest Hamel; Giuseppe Daidone
Journal:  Eur J Med Chem       Date:  2013-05-14       Impact factor: 6.514

2.  Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy.

Authors:  Jonathan M Viney; David P Andrew; Rhian M Phillips; Andrea Meiser; Pallavi Patel; Melissa Lennartz-Walker; David J Cousins; Nicholas P Barton; David A Hall; James E Pease
Journal:  J Immunol       Date:  2014-02-21       Impact factor: 5.422

3.  Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality.

Authors:  Demetrio Raffa; Benedetta Maggio; Fabiana Plescia; Stella Cascioferro; Maria Valeria Raimondi; Gabriella Cancemi; Antonella D'Anneo; Marianna Lauricella; Maria Grazia Cusimano; Ruoli Bai; Ernest Hamel; Giuseppe Daidone
Journal:  Bioorg Med Chem       Date:  2015-08-28       Impact factor: 3.641

4.  New drugs targeting Th2 lymphocytes in asthma.

Authors:  Gaetano Caramori; David Groneberg; Kazuhiro Ito; Paolo Casolari; Ian M Adcock; Alberto Papi
Journal:  J Occup Med Toxicol       Date:  2008-02-27       Impact factor: 2.646

5.  Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.

Authors:  Thomas S Dexheimer; Andrew S Rosenthal; Diane K Luci; Qin Liang; Mark A Villamil; Junjun Chen; Hongmao Sun; Edward H Kerns; Anton Simeonov; Ajit Jadhav; Zhihao Zhuang; David J Maloney
Journal:  J Med Chem       Date:  2014-09-17       Impact factor: 7.446

6.  A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma.

Authors:  Yang Zhang; Yinfang Wu; Hui Qi; Junhai Xiao; Hongwei Gong; Yan Zhang; Enquan Xu; Song Li; Dalong Ma; Ying Wang; Wen Li; Huahao Shen
Journal:  Sci Rep       Date:  2017-11-08       Impact factor: 4.379

7.  Design and synthesis of a series of pyrido[2,3-d]pyrimidine derivatives as CCR4 antagonists.

Authors:  Hongwei Gong; Hui Qi; Wei Sun; Yang Zhang; Dan Jiang; Junhai Xiao; Xiaohong Yang; Ying Wang; Song Li
Journal:  Molecules       Date:  2012-08-20       Impact factor: 4.411
  7 in total

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